Back to Search
Start Over
Circulating prostaglandin E2: a novel potential prognostic biomarker in patients with hepatocellular carcinoma
- Source :
- Clinical and Experimental Medicine. 21:675-682
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- We aimed to explore the activation of monoacylglycerol lipase (MAGL)/cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) axis in hepatocellular carcinoma (HCC), evaluating circulating PGE2 as prognostic biomarker in HCC patients. PGE2 levels were measured in blood samples from 24 cirrhotics, and 34 HCC patients were consecutively collected between January 2016 and December 2017. In a subgroup of patients, tissue expression of MAGL mRNA and immunohistochemistry for MAGL and COX-2 were obtained. Despite tumor tissues showing overexpression of MAGL mRNA and higher levels of both MAGL and COX-2 at immunohistochemistry, PGE2 levels were not significantly different in HCC and cirrhotics. HCC patients with circulating PGE2 levels > 14 pg/mL had a significantly shorter overall survival (19.4 vs. 49.9 months; p = 0.03), the finding being confirmed by the multivariate analysis (HR 3.37 [95% CI 1.00–11.60]; p = 0.05). The MAGL/COX-2/PGE2 axis is activated in HCC, and circulating PGE2 proved to be a potential prognostic biomarker.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Survival
Hepatocellular carcinoma
medicine.medical_treatment
Monoacylglycerol lipase
Cyclooxygenase-2
Prostaglandin E
2
Gastroenterology
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Internal medicine
Medicine
Prognostic biomarker
In patient
Prostaglandin E2
Hematology
business.industry
General Medicine
medicine.disease
digestive system diseases
030104 developmental biology
030220 oncology & carcinogenesis
Immunohistochemistry
lipids (amino acids, peptides, and proteins)
business
medicine.drug
Subjects
Details
- ISSN :
- 15919528 and 15918890
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Clinical and Experimental Medicine
- Accession number :
- edsair.doi.dedup.....64ff74fe4ba3601c24da19bccae2ece1