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X monosomy in a virilized female cat
- Source :
- Reproduction in domestic animals = Zuchthygiene. 50(2)
- Publication Year :
- 2014
-
Abstract
- An infertile Siamese female cat was subjected for clinical, histological, cytogenetic and molecular studies due to ambiguous external genitalia (vulva, vagina, rudimentary penis and scrotum-like structure) and masculine behaviour. An elevated oestrogen activity and a detectable level of testosterone were found. The cat underwent laparotomy. The gonads and the uterus were removed and subjected for histological studies, which showed ovaries with corpora lutea and a some primordial follicles. Chromosome studies of lymphocyte and fibroblast cultures, with the use of Giemsa staining, G-banding and whole X chromosome painting by fluorescence in situ hybridization, revealed pure X monosomy. Molecular analysis showed the absence of the SRY gene. Our study revealed for the first time that X monosomy in cats may be associated with virilization, in spite of the lack of the SRY gene.
- Subjects :
- endocrine system
medicine.medical_specialty
Monosomy
Uterus
Disorders of Sex Development
Aneuploidy
Biology
Cat Diseases
Andrology
Endocrinology
Internal medicine
medicine
Animals
X chromosome
Sex Chromosome Aberrations
medicine.diagnostic_test
urogenital system
Virilization
medicine.disease
Virilism
medicine.anatomical_structure
Testis determining factor
Cats
Animal Science and Zoology
Female
medicine.symptom
Penis
Biotechnology
Fluorescence in situ hybridization
Subjects
Details
- ISSN :
- 14390531
- Volume :
- 50
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Reproduction in domestic animals = Zuchthygiene
- Accession number :
- edsair.doi.dedup.....6502d080a6112691ce3a24277eed35b8