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Efficacy and safety of switching from rituximab to biosimilar CT-P10 in rheumatoid arthritis: 72-week data from a randomized Phase 3 trial
- Source :
- Rheumatology (Oxford, England)
- Publication Year :
- 2019
- Publisher :
- Oxford University Press (OUP), 2019.
-
Abstract
- Objective To evaluate the efficacy and safety of CT-P10, a rituximab biosimilar after a single switch, during a multinational, randomized, double-blind Phase 3 trial involving patients with RA. Methods Patients received 48 weeks’ treatment with CT-P10 or United States- or European Union-sourced reference rituximab (US-RTX and EU-RTX, respectively). Patients entering the extension period (weeks 48–72) remained on CT-P10 (CT-P10/CT-P10; n = 122) or US-RTX (US-RTX/US-RTX; n = 64), or switched to CT-P10 from US-RTX (US-RTX/CT-P10; n = 62) or EU-RTX (EU-RTX/CT-P10; n = 47) for an additional course. Efficacy endpoints included Disease Activity Score using 28 joints (DAS28), American College of Rheumatology (ACR) response rates, and quality of life-related parameters. Pharmacodynamics, immunogenicity and safety were also assessed. Results At week 72, similar improvements were observed by disease activity parameters including DAS28 and ACR response rate in the four extension period treatment groups. Quality of life improvements at week 72 vs baseline were similarly shown during the extension period in all groups. Newly developed anti-drug antibodies were detected in two patients following study drug infusion in the extension period. Similar pharmacodynamic and safety profiles were observed across groups. Conclusion Long-term use of CT-P10 up to 72 weeks was effective and well tolerated. Furthermore, switching from reference rituximab to CT-P10 in RA was well tolerated and did not result in any clinically meaningful differences in terms of efficacy, pharmacodynamics, immunogenicity and safety. Trail registration ClinicalTrials.gov, http://clinicaltrials.gov, NCT02149121.
- Subjects :
- rheumatoid arthritis
Adult
Male
medicine.medical_specialty
DMARDs (biologic)
Arthritis, Rheumatoid
Antibodies, Monoclonal, Murine-Derived
03 medical and health sciences
rituximab
0302 clinical medicine
Double-Blind Method
Rheumatology
Quality of life
Internal medicine
medicine
Humans
Pharmacology (medical)
skin and connective tissue diseases
Biosimilar Pharmaceuticals
030203 arthritis & rheumatology
Response rate (survey)
B cells
Drug Substitution
business.industry
Surrogate endpoint
Immunogenicity
anti-TNF
Clinical Science
Middle Aged
medicine.disease
switch
United States
Europe
Treatment Outcome
Antirheumatic Agents
030220 oncology & carcinogenesis
Pharmacodynamics
Rheumatoid arthritis
Quality of Life
Female
Rituximab
biosimilar
business
CT-P10
disease activity
medicine.drug
Subjects
Details
- ISSN :
- 14620332 and 14620324
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Rheumatology
- Accession number :
- edsair.doi.dedup.....650450e531d93732fb56232203629d15
- Full Text :
- https://doi.org/10.1093/rheumatology/kez152