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Hyperhomocysteinemia: an instigating factor for periodontal disease
- Source :
- Canadian Journal of Physiology and Pharmacology. 99:115-123
- Publication Year :
- 2021
- Publisher :
- Canadian Science Publishing, 2021.
-
Abstract
- Hyperhomocysteinemia (HHcy) affects bone remodeling, since a destructive process in cortical alveolar bone has been linked to it; however, the mechanism remains at large. HHcy increases proinflammatory cytokines viz. TNF-α, IL-1b, IL-6, and IL-8 that leads to a cascade that negatively impacts methionine metabolism and homocysteine cycling. Further, chronic inflammation decreases vitamins B12, B6, and folic acid that are required for methionine homocysteine homeostasis. This study aims to investigate a HHcy mouse model (cystathionine β-synthase deficient, CBS+/–) for studying the potential pathophysiological changes, if any, in the periodontium (gingiva, periodontal ligament, cement, and alveolar bone). We compared the periodontium side-by-side in the CBS+/– model with that of the wild-type (C57BL/6J) mice. Histology and histomorphometry of the mandibular bone along with gene expression analyses were carried out. Also, proangiogenic proteins and metalloproteinases were studied. To our knowledge, this research shows, for the first time, a direct connection between periodontal disease during CBS deficiency, thereby suggesting the existence of disease drivers during the hyperhomocysteinemic condition. Our findings offer opportunities to develop diagnostics/therapeutics for people who suffer from chronic metabolic disorders like HHcy.
- Subjects :
- Male
Periodontium
0301 basic medicine
medicine.medical_specialty
Hyperhomocysteinemia
Homocysteine
Physiology
Cystathionine beta-Synthase
Mice, Transgenic
Bone remodeling
Proinflammatory cytokine
Mice
03 medical and health sciences
chemistry.chemical_compound
Folic Acid
0302 clinical medicine
Physiology (medical)
Internal medicine
Animals
Humans
Medicine
Periodontal fiber
Periodontitis
Dental alveolus
Pharmacology
biology
business.industry
030206 dentistry
General Medicine
medicine.disease
Cystathionine beta synthase
Disease Models, Animal
Oxidative Stress
030104 developmental biology
Endocrinology
chemistry
biology.protein
business
Subjects
Details
- ISSN :
- 12057541 and 00084212
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Canadian Journal of Physiology and Pharmacology
- Accession number :
- edsair.doi.dedup.....650ded85666dfb377bec1e3aa4ebc357