Biological versus mechanical heart valve prosthesis during pregnancy in women with congenital heart disease

Background: We evaluate pregnancy outcome and anticoagulation regimes in women with mechanical and biological prosthetic heart valves (PHV) for congenital heart disease. Methods: Retrospective multicenter cohort studying pregnancy outcomes in an existing cohort of patients with PHV. Results: 52 women had 102 pregnancies of which 78 pregnancies (46 women) ≥20 weeks duration (59 biological, 19 mechanical PHV). Miscarriages (n = 19, ≤20 weeks) occurred more frequently in women using anticoagulation (P