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Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring
- Source :
- International Journal of Obesity (2005)
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- Objectives: Low birth weight (LBW) has been associated with common adult-onset chronic diseases, including obesity, cardiovascular disease, type II diabetes and some cancers. The etiology of LBW is multi-factorial. However, recent evidence suggests exposure to antibiotics may also increase the risk of LBW. The mechanisms underlying this association are unknown, although epigenetic mechanisms are hypothesized. In this study, we evaluated the association between maternal antibiotic use and LBW and examined the potential role of altered DNA methylation that controls growth regulatory imprinted genes in these associations. Methods: Between 2009–2011, 397 pregnant women were enrolled and followed until delivery. Prenatal antibiotic use was ascertained through maternal self-report. Imprinted genes methylation levels were measured at differentially methylated regions (DMRs) using bisulfite pyrosequencing. Generalized linear models were used to examine associations among antibiotic use, birth weight and DMR methylation fractions. Results: After adjusting for infant gender, race/ethnicity, maternal body mass index, delivery route, gestational weight gain, gestational age at delivery, folic acid intake, physical activity, maternal smoking and parity, antibiotic use during pregnancy was associated with 138 g lower birth weight compared with non-antibiotic use (β-coefficient=−132.99, s.e.=50.70, P=0.008). These associations were strongest in newborns of women who reported antibiotic use other than penicillins (β-coefficient=−135.57, s.e.=57.38, P=0.02). Methylation at five DMRs, IGF2 (P=0.05), H19 (P=0.15), PLAGL1 (P=0.01), MEG3 (P=0.006) and PEG3 (P=0.08), was associated with maternal antibiotic use; among these, only methylation at the PLAGL1 DMR was also associated with birth weight. Conclusion: We report an inverse association between in utero exposure to antibiotics and lower infant birth weight and provide the first empirical evidence supporting imprinted gene plasticity in these associations.
- Subjects :
- newborns
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
Physiology
Cell Cycle Proteins
antibiotics
Epigenesis, Genetic
Fetal Development
0302 clinical medicine
Pregnancy
Neoplasms
Birth Weight
Prospective Studies
race
2. Zero hunger
0303 health sciences
Nutrition and Dietetics
Pediatric Original Article
Anti-Bacterial Agents
3. Good health
Cardiovascular Diseases
Prenatal Exposure Delayed Effects
030220 oncology & carcinogenesis
DNA methylation
Intercellular Signaling Peptides and Proteins
Female
RNA, Long Noncoding
medicine.symptom
Adult
medicine.medical_specialty
Offspring
Birth weight
Kruppel-Like Transcription Factors
Nerve Tissue Proteins
Biology
Genomic Imprinting
03 medical and health sciences
Insulin-Like Growth Factor II
Sarcoglycans
Internal medicine
medicine
Humans
Obesity
Epigenetics
030304 developmental biology
epigenetics
Tumor Suppressor Proteins
Calcium-Binding Proteins
Infant, Newborn
Membrane Proteins
Proteins
Sequence Analysis, DNA
DNA Methylation
Infant, Low Birth Weight
medicine.disease
United States
Low birth weight
Endocrinology
Genomic imprinting
Weight gain
Transcription Factors
Subjects
Details
- ISSN :
- 14765497 and 03070565
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- International Journal of Obesity
- Accession number :
- edsair.doi.dedup.....65313c964fd8ee6de0d433cd637d2928