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Disparities in Treatment with Direct-Acting Hepatitis C Virus Antivirals Persist Among Adults Coinfected with HIV and Hepatitis C Virus in US Clinics, 2010–2018
- Source :
- AIDS Patient Care and STDs. 35:392-400
- Publication Year :
- 2021
- Publisher :
- Mary Ann Liebert Inc, 2021.
-
Abstract
- Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfection carries substantial risk for all-cause mortality and liver-related morbidity and mortality, yet many persons coinfected with HIV/HCV remain untreated for HCV. We explored demographic, clinical, and sociodemographic factors among participants in routine HIV care associated with prescription of direct-acting antivirals (DAAs). The HIV Outpatient Study (HOPS) is an ongoing longitudinal cohort study of persons with HIV in care at participating clinics since 1993. There are currently eight study sites in six US cities. We analyzed medical records data of HOPS participants diagnosed with HCV since June 2010. Sustained virological response (SVR) was documented with first undetectable HCV viral load (VL). We assessed factors associated with being prescribed DAAs by multi-variable logistic regression and described the cumulative rate of SVR. Among 306 eligible participants, 131 (43%) were prescribed DAA therapy. Factors associated with greater odds of being prescribed DAA were older age, private health insurance, higher CD4 cell count, being a person who injects drugs, and receiving care at publicly funded sites (
- Subjects :
- Adult
viruses
Hepatitis C virus
Human immunodeficiency virus (HIV)
HIV Infections
Hepacivirus
medicine.disease_cause
Antiviral Agents
medicine
Humans
Longitudinal Studies
Aged
Coinfection
business.industry
Public Health, Environmental and Occupational Health
virus diseases
Hepatitis C, Chronic
medicine.disease
Hepatitis C
Virology
Treatment Outcome
Infectious Diseases
Pharmaceutical Preparations
business
Direct acting
Subjects
Details
- ISSN :
- 15577449 and 10872914
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- AIDS Patient Care and STDs
- Accession number :
- edsair.doi.dedup.....6543dcda4e9e0ccea6a4c8591514f87b