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Prevalence of drug resistance mutations in HIV-infected individuals with low-level viraemia under combination antiretroviral therapy: an observational study in a tertiary hospital in Northern Taiwan, 2017-19
- Source :
- The Journal of antimicrobial chemotherapy. 76(3)
- Publication Year :
- 2020
-
Abstract
- Background Effective ART is crucial for combating the HIV pandemic. Clinically, plasma viral load monitoring to achieve virological suppression is the guide for an optimal ART. The presence of low-level viraemia (LLV) below the definition level of virological failure is a risk factor for ART failure. However, there is no treatment consensus over LLV yet, mainly due to the limitation of standard HIV-RNA genotyping and the resultant insufficient understanding of LLV characteristics. Objectives To better profile drug resistance mutations (DRMs) and the associated factors in cases experiencing LLV. Methods A prospective observational study was conducted from 2017 to 2019. HIV-DNA was used as an alternative to HIV-RNA for HIV genotyping coupled with deep sequencing for ART-naive and ART-failure cases, as well as those with LLV. Results Eighty-one ART-naive, 18 ART-failure and 16 LLV cases received HIV genotyping in the study. Three-quarters (12/16) of cases experiencing LLV harboured DRMs. Cases with LLV had higher prevalence of DRMs to NNRTIs than the ART-naive group (69% versus 20%, P Conclusions HIV DRM profiles in LLV cases were significantly different to those in ART-naive and ART-failure cases. Approaches to consolidate ART compliance and early exploration of potential ART resistance may be needed for cases experiencing LLV episodes.
- Subjects :
- Microbiology (medical)
medicine.medical_specialty
Anti-HIV Agents
Human immunodeficiency virus (HIV)
Taiwan
Viremia
HIV Infections
Drug resistance
medicine.disease_cause
Tertiary Care Centers
Internal medicine
Pandemic
Drug Resistance, Viral
medicine
Prevalence
Humans
Pharmacology (medical)
Risk factor
Genotyping
Pharmacology
business.industry
Viral Load
medicine.disease
Infectious Diseases
Mutation
HIV-1
Observational study
business
Viral load
Subjects
Details
- ISSN :
- 14602091
- Volume :
- 76
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The Journal of antimicrobial chemotherapy
- Accession number :
- edsair.doi.dedup.....6565031c60e3e9b39beac81d617379d1