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Smart Metal–Organic Framework-Based Nanoplatforms for Imaging-Guided Precise Chemotherapy
- Source :
- ACS Applied Materials & Interfaces. 11:1886-1895
- Publication Year :
- 2018
- Publisher :
- American Chemical Society (ACS), 2018.
-
Abstract
- Good biocompatibility, active tumor targeting, and stimulus-responsive release offer great opportunity for precise imaging-guided tumor treatment. However, the current strategies for the fabrication of smart theranostic platforms suffer from tedious synthesis processes. Here, we propose a universal and facile strategy for the fabrication of smart nanoscale metal-organic framework (NMOF)-based nanoplatforms for imaging-guided precise chemotherapy. As a proof of concept, 5-boronobenzene-1,3-dicarboxylic acid (BBDC), as a versatile ligand, was employed for the first time with Gd3+ as metal nodes to prepare a smart magnetic resonance (MR) imaging-guided drug-delivery system. Specific reversible diol-borate condensation enables effortless coating of glucose on the NMOFs to improve their biocompatibility. The specific interaction between glucose and glucose-transported protein ensures active tumor-targeting ability. Moreover, the glucose layer, as a pH-responsive diol-borate gatekeeper, prevents the premature leakage of drugs. The proposed smart theranostic nanoplatform was well used in MR imaging-guided tumor-targeted precise chemotherapy. This strategy is simply extended to the design of other MOF-glucose composites for diverse applications, such as X-ray computed tomography imaging of gastrointestinal tract with Yb-MOFs-Glu. BBDC, as a functional ligand, provides a simple and universal way to fabricate smart NMOF theranostic platforms with multifunction as "three birds with one stone". The facile and universal strategy lays down a new way to develop multifunctional nanoagents for precision medicine.
- Subjects :
- Tumor targeting
Materials science
Contrast Media
Gadolinium
Nanotechnology
Computed tomography
02 engineering and technology
010402 general chemistry
01 natural sciences
Mice
Drug Delivery Systems
medicine
Animals
Humans
General Materials Science
Metal-Organic Frameworks
medicine.diagnostic_test
technology, industry, and agriculture
Tumor therapy
Neoplasms, Experimental
021001 nanoscience & nanotechnology
Magnetic Resonance Imaging
Mr imaging
0104 chemical sciences
Targeted drug delivery
Doxorubicin
Proof of concept
0210 nano-technology
HeLa Cells
Subjects
Details
- ISSN :
- 19448252 and 19448244
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- ACS Applied Materials & Interfaces
- Accession number :
- edsair.doi.dedup.....65a171cbb5d5dd8a2d58d516d29c99c4