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The Role of PSA-NCAM in Adult Neurogenesis
- Source :
- Neurochemical Research (2008), Advances in Experimental Medicine and Biology, Vol. 663 (2010) pp. 127-136
- Publication Year :
- 2008
- Publisher :
- Springer Science and Business Media LLC, 2008.
-
Abstract
- Recruitment of new neurons to existing circuits is a fascinating form of adult plasticity. In the mammalian brain, this process occurs in two discrete regions, the subventricular zone of the lateral ventricule (SVZ) and the subgranular zone of dentate gyrus (SGZ) in the hippocampus. Several recent studies suggest that isoforms of the neuronal cell adhesion molecule (NCAM) carrying the linear homopolymer of alpha 2,8-linked sialic acid (polysialic acid, PSA), play a role in regulating several steps of adult neurogenesis including migration, survival and process outgrowth of newly generated neurons. Here, we will review recent evidence on how PSA-NCAM might regulate the biological properties of new neurons in sites of adult neurogenesis.
- Subjects :
- Cell Survival
Neurogenesis
Neural Cell Adhesion Molecule L1/genetics/ metabolism
Sialic Acids/genetics/ metabolism
Subventricular zone
Hippocampus
Neural Cell Adhesion Molecule L1
Biology
Biochemistry
Subgranular zone
Cellular and Molecular Neuroscience
Stem Cells/cytology/physiology
Cell Movement
medicine
Neurons/cytology/ physiology
Animals
Neurons
Polysialic acid
Stem Cells
Dentate gyrus
Cell Movement/physiology
Brain
Cell Differentiation
General Medicine
Neurogenesis/ physiology
ddc:616.8
Brain/anatomy & histology/physiology
medicine.anatomical_structure
nervous system
Sialic Acids
Neural cell adhesion molecule
Neuronal Cell Adhesion Molecule
Neuroscience
Subjects
Details
- ISSN :
- 15736903, 03643190, and 00652598
- Database :
- OpenAIRE
- Journal :
- Neurochemical Research
- Accession number :
- edsair.doi.dedup.....65a2055a56a81d04b3e2cf3fd1f64c4e