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Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'
- Source :
- eLife, Vol 8 (2019), eLife
- Publication Year :
- 2019
- Publisher :
- eLife Sciences Publications Ltd, 2019.
-
Abstract
- In 2016, we reported four substantial observations of APECED/APS1 patients, who are deficient in AIRE, a major regulator of central T cell tolerance (Meyer et al., 2016). Two of those observations have been challenged. Specifically, ‘private’ autoantibody reactivities shared by only a few patients but collectively targeting >1000 autoantigens have been attributed to false positives (Landegren, 2019). While acknowledging this risk, our study-design included follow-up validation, permitting us to adopt statistical approaches to also limit false negatives. Importantly, many such private specificities have now been validated by multiple, independent means including the autoantibodies’ molecular cloning and expression. Second, a significant correlation of antibody-mediated IFNα neutralization with an absence of disease in patients highly disposed to Type I diabetes has been challenged because of a claimed failure to replicate our findings (Landegren, 2019). However, flaws in design and implementation invalidate this challenge. Thus, our results present robust, insightful, independently validated depictions of APECED/APS1, that have spawned productive follow-up studies.
- Subjects :
- 0301 basic medicine
immune tolerance
medicine
type 1 diabetes
Disease
Immune tolerance
immunology
human B cell biology
0302 clinical medicine
Immunology and Inflammation
2.1 Biological and endogenous factors
Aetiology
Biology (General)
Polyendocrinopathies, Autoimmune
General Neuroscience
human biology
General Medicine
autoantigen
autoantibodies and disease
Interferon Type I
Medicine
medicine.symptom
Scientific Correspondence
Type 1
Human
QH301-705.5
Science
Inflammation
Autoimmune Disease
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Clinical Research
Diabetes Mellitus
Humans
In patient
APS1/APECED
human
Human Biology and Medicine
Gene
Metabolic and endocrine
Autoantibodies
Type 1 diabetes
General Immunology and Microbiology
business.industry
Autoantibody
Immunology in the medical area
medicine.disease
030104 developmental biology
Diabetes Mellitus, Type 1
Polyendocrinopathies
inflammation
Immunologi inom det medicinska området
Immunology
Biochemistry and Cell Biology
business
030217 neurology & neurosurgery
autoantibody
Autoimmune
Transcription Factors
Subjects
Details
- Language :
- English
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- eLife
- Accession number :
- edsair.doi.dedup.....65c093598f501208f68543ca8e850baa