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Sex and bacterial infectious diseases
- Source :
- New Microbes and New Infections, Vol 26, Iss, Pp S100-S103 (2018), New Microbes and New Infections, New Microbes and New Infections, 2018, 26, pp.S100-S103. ⟨10.1016/j.nmni.2018.05.010⟩, New Microbes and New Infections, Wiley Online Library 2018, 26, pp.S100-S103. ⟨10.1016/j.nmni.2018.05.010⟩
- Publication Year :
- 2018
- Publisher :
- Elsevier, 2018.
-
Abstract
- Most infectious diseases are unequally distributed between male and female subjects. This sex dimorphism is confirmed by epidemiologic studies which suggest an increased number of male septic patients, while, due to the class age of septic patients, an overrepresentation of female patients would be expected. Lifestyle, recreational activities, professional exposition and access to care are plausible reasons for this dimorphism. However, biological differences should be carefully considered, particularly the weight of X-linked variability and the role of sex hormones. Animal models clearly show that clinical response to infection is more exuberant in males than in females. This is partly explained by an attenuation of the inflammatory response by female sex hormones. However, the translation from experimental studies to the bedside remains challenging as a result of confounding factors like age, hormone changes and response to treatment. Keywords: Bacteria, estradiol, gender, infection, sex
- Subjects :
- Paper
0301 basic medicine
Female sex hormones
Inflammatory response
Physiology
[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics
Microbiology
lcsh:Infectious and parasitic diseases
03 medical and health sciences
0302 clinical medicine
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
estradiol
BACTERIAL INFECTIOUS DISEASES
Female patient
gender
sex
Medicine
lcsh:RC109-216
ComputingMilieux_MISCELLANEOUS
Bacteria
business.industry
Confounding
030208 emergency & critical care medicine
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Response to treatment
infection
3. Good health
Sexual dimorphism
030104 developmental biology
Infectious Diseases
business
Hormone
Subjects
Details
- Language :
- English
- ISSN :
- 20522975
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- New Microbes and New Infections
- Accession number :
- edsair.doi.dedup.....65fdd2c7afd59687c05164e7fe1d36ea