Back to Search
Start Over
Leptin is an effective treatment for hypothalamic amenorrhea
- Source :
- Proceedings of the National Academy of Sciences of the United States of America 108 (2011): 6585–6590., info:cnr-pdr/source/autori:Chou SH, Chamberland JP, Liu X, Matarese G, Gao C, Stefanakis R, Brinkoetter MT, Gong H, Arampatzi K, Mantzoros CS./titolo:Leptin is an effective treatment for hypothalamic amenorrhea./doi:/rivista:Proceedings of the National Academy of Sciences of the United States of America/anno:2011/pagina_da:6585/pagina_a:6590/intervallo_pagine:6585–6590/volume:108
- Publication Year :
- 2011
- Publisher :
- National Academy of Sciences, 2011.
-
Abstract
- Hypothalamic amenorrhea (HA) is associated with dysfunction of the hypothalamic-pituitary-peripheral endocrine axes, leading to infertility and bone loss, and usually is caused by chronic energy deficiency secondary to strenuous exercise and/or decreased food intake. Energy deficiency also leads to hypoleptinemia, which has been proposed, on the basis of observational studies as well as an open-label study, to mediate the neuroendocrine abnormalities associated with this condition. To prove definitively a causal role of leptin in the pathogenesis of HA, we performed a randomized, double-blinded, placebo-controlled trial of human recombinant leptin (metreleptin) in replacement doses over 36 wk in women with HA. We assessed its effects on reproductive outcomes, neuroendocrine function, and bone metabolism. Leptin replacement resulted in recovery of menstruation and corrected the abnormalities in the gonadal, thyroid, growth hormone, and adrenal axes. We also demonstrated changes in markers of bone metabolism suggestive of bone formation, but no changes in bone mineral density were detected over the short duration of this study. If these data are confirmed, metreleptin administration in replacement doses to normalize circulating leptin levels may prove to be a safe and effective therapy for women with HA.
- Subjects :
- Adult
Leptin
medicine.medical_specialty
Hypothalamo-Hypophyseal System
Time Factors
Adolescent
Pituitary-Adrenal System
030209 endocrinology & metabolism
Hypothalamic disease
Bone remodeling
Feeding and Eating Disorders
03 medical and health sciences
Metreleptin
chemistry.chemical_compound
Eating
0302 clinical medicine
Internal medicine
medicine
Endocrine system
Humans
Amenorrhea
030304 developmental biology
2. Zero hunger
Bone mineral
0303 health sciences
Multidisciplinary
business.industry
Thyroid
Biological Sciences
medicine.disease
3. Good health
Endocrinology
medicine.anatomical_structure
chemistry
Female
medicine.symptom
business
Hypothalamic Diseases
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America 108 (2011): 6585–6590., info:cnr-pdr/source/autori:Chou SH, Chamberland JP, Liu X, Matarese G, Gao C, Stefanakis R, Brinkoetter MT, Gong H, Arampatzi K, Mantzoros CS./titolo:Leptin is an effective treatment for hypothalamic amenorrhea./doi:/rivista:Proceedings of the National Academy of Sciences of the United States of America/anno:2011/pagina_da:6585/pagina_a:6590/intervallo_pagine:6585–6590/volume:108
- Accession number :
- edsair.doi.dedup.....6603b24322cca809ff9e4bc59a54e4bb