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High frequency of mutation of epidermal growth factor receptor in lung adenocarcinoma in Thailand
- Source :
- Cancer Letters. 239:292-297
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Recent reports have suggested influences of racial difference on the frequency of mutation of EGFR in lung cancer. We therefore sought to characterize the frequency and pattern of mutation of EGFR in lung adenocarcinoma in Thai patients. Overall, EGFR catalytic domain mutations were detected in 35/61 (57.4%). We found 29/60 (48.3%) of exon 19 deletions, 5/54 (9.3%) of exon 21 point mutations, and 1/54 (1.9%) of double-mutation of both exons. The presence of these mutations was significantly associated with non-smoking habit. In summary, we report a strikingly high prevalence of mutation of EGFR in Thai lung adenocarcinoma, which may explain the high response rate to the treatment with TKI among Asian populations.
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
Lung Neoplasms
medicine.drug_class
Molecular Sequence Data
Adenocarcinoma
Biology
medicine.disease_cause
Tyrosine-kinase inhibitor
Exon
Gefitinib
Internal medicine
medicine
Humans
Amino Acid Sequence
Epidermal growth factor receptor
Lung cancer
Mutation
Base Sequence
Sequence Homology, Amino Acid
Point mutation
Exons
Thailand
medicine.disease
ErbB Receptors
Cancer research
biology.protein
medicine.drug
Subjects
Details
- ISSN :
- 03043835
- Volume :
- 239
- Database :
- OpenAIRE
- Journal :
- Cancer Letters
- Accession number :
- edsair.doi.dedup.....660794d21bc227bdb30a354e7b63e4da