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Remodeling of hippocampal network in pilocarpine-treated mice expressing synaptopHluorin in the mossy fiber terminals
- Source :
- Neuroscience Research. 74:25-31
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Pilocarpine-induced seizures induce an ectopic projection of hippocampal mossy fibers (MFs). Here, the sprouting was directly examined using TV-42 mice that express synaptopHluorin (SpH) selectively in the MF boutons. The SpH was ectopically expressed in the inner molecular layer (IML) of the dentate gyrus in typical mice after seizures, but were not always accompanied by the zinc fluorescence. The expression of SpH also has a tendency to be enhanced in layers of the CA3a region. It is suggested that the abnormal connection of neurons is more widespread than expected based on the previous zinc-detecting methods.
- Subjects :
- Mossy fiber (hippocampus)
Recombinant Fusion Proteins
Green Fluorescent Proteins
Synaptogenesis
Hippocampus
Convulsants
Hippocampal formation
Mice
Epilepsy
Seizures
Neural Pathways
medicine
Animals
Chemistry
General Neuroscience
Dentate gyrus
Pilocarpine
General Medicine
medicine.disease
Immunohistochemistry
Mice, Inbred C57BL
Mossy Fibers, Hippocampal
Neuroscience
Sprouting
medicine.drug
Subjects
Details
- ISSN :
- 01680102
- Volume :
- 74
- Database :
- OpenAIRE
- Journal :
- Neuroscience Research
- Accession number :
- edsair.doi.dedup.....662a607eb91a38de30a86bf872547643