Comparison Between Cefotiam And Cefotiam / Netilmycin Antibiotic Therapy for Grade III Open Tibial Fractures

We studied the effect of the addition of the bacteriostatic agent, netilmycin, to cefotiam treatment as prophylactic antibiotics against infection for grade III open tibial fractures. From 45 eligible cases, assigned randomly to a control group that receive only cefotiam, and the treatment group that receive netilmycin in addition to cefotiam. We observed that the clearing of infection occurred earlier in the cefotiam /netilmycin group. We found that 3-day administration of cefotiam-netilmycin is superior to 3-day administration of cefotiam only. It is equivalent to 5-day treatment with cefotiam alone.