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Inflammatory Disease and Lymphomagenesis Caused by Deletion of the Myc Antagonist Mnt in T Cells
- Source :
- Molecular and Cellular Biology. 26:2080-2092
- Publication Year :
- 2006
- Publisher :
- Informa UK Limited, 2006.
-
Abstract
- Mnt is a Max-interacting protein that can antagonize the activities of Myc oncoproteins in cultured cells. Mnt null mice die soon after birth, but conditional deletion of Mnt in breast epithelium leads to tumor formation. These and related data suggest that Mnt functions as a tumor suppressor. Here we show that conditional deletion of Mnt in T cells leads to tumor formation but also causes inflammatory disease. Deletion of Mnt caused increased apoptosis of thymic T cells and interfered with T-cell development yet led to spleen, liver, and lymph node enlargement. The proportion of T cells in the spleen and lymph nodes was reduced, and the numbers of cells in non-T-cell immune cell populations were elevated. The disruption of immune homeostasis is linked to a strong skewing toward production of T-helper 1 (Th1) cytokines and enhanced proliferation of activated Mnt-deficient CD4+ T cells. Consistent with Th1 polarization in vivo, extensive intestinal inflammation and liver necrosis developed. Finally, most mice lacking Mnt in T cells ultimately succumbed to T-cell lymphoma. These results strengthen the argument that Mnt functions as a tumor suppressor and reveal a critical and surprising role for Mnt in the regulation of T-cell development and in T-cell-dependent immune homeostasis.
- Subjects :
- CD4-Positive T-Lymphocytes
Necrosis
T-Lymphocytes
Cell
Apoptosis
Spleen
Inflammation
Thymus Gland
Biology
Lymphoma, T-Cell
Proto-Oncogene Proteins c-myc
Mice
Immune system
medicine
Animals
Molecular Biology
Lymph node
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Articles
Organ Size
Cell Biology
Th1 Cells
medicine.disease
Mice, Mutant Strains
Lymphoma
Intestines
Repressor Proteins
medicine.anatomical_structure
Gene Expression Regulation
Liver
Cancer research
medicine.symptom
Subjects
Details
- ISSN :
- 10985549
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Molecular and Cellular Biology
- Accession number :
- edsair.doi.dedup.....666161ba388780035c4a1e7af8720a90
- Full Text :
- https://doi.org/10.1128/mcb.26.6.2080-2092.2006