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Prognostic nutritional index may not be a good prognostic indicator for acute myocardial infarction
- Source :
- Scientific Reports, Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- The prognostic nutritional index (PNI) has been applied in acute myocardial infarction (AMI) recently.However, the application of PNI in AMI needs verification. This was a prospective cohort study. Patients diagnosed with AMI were enrolled. PNI was calculated as (serum albumin (SA in g/L)) + (5 × total lymphocyte count (TLC) × 109/L). Modified PNI (mPNI) was analyzed by logistic regression analysis to reset the proportion of SA and TLC. The primary outcome was all-cause death. A total of 598 patients were enrolled; 73 patients died during follow-up. The coefficient of SA and TLC in the mPNI formula was approximately 2:1. The area under the receiver operating characteristic curve of SA, TLC, PNI, mPNI and GRACE in predicting death for patients with AMI was 0.718, 0.540, 0.636, 0.721 and 0.825, respectively. Net reclassification improvement (NRI) between PNI and mPNI was 0.230 (p p = 0.001). Decision curve analysis revealed that mPNI had better prognostic value for patients with AMI than PNI; however, it was not superior to SA. Thus, PNI may not a reliable prognostic predictor of AMI; after resetting the formula, the value of PNI in predicting prognosis of AMI is almost entirely due to SA.
- Subjects :
- Male
medicine.medical_specialty
Science
Myocardial Infarction
Nutritional Status
Serum Albumin, Human
Kaplan-Meier Estimate
030204 cardiovascular system & hematology
Logistic regression
Gastroenterology
Article
Prognostic markers
03 medical and health sciences
0302 clinical medicine
Primary outcome
Internal medicine
medicine
Humans
cardiovascular diseases
Lymphocyte Count
Prospective Studies
030212 general & internal medicine
Myocardial infarction
Prospective cohort study
Aged
Aged, 80 and over
Multidisciplinary
Receiver operating characteristic
business.industry
Middle Aged
Prognosis
medicine.disease
Net reclassification improvement
Logistic Models
Nutrition Assessment
Risk factors
Decision curve analysis
Integrated discrimination improvement
Area Under Curve
Medicine
Female
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....666e0db77d9ee3c8cf919f752c40e641