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Induction chemotherapy in head and neck cancers: Results and controversies
- Source :
- Oral Oncology, Oral Oncology, Elsevier, 2019, 95, pp.164-169. ⟨10.1016/j.oraloncology.2019.06.015⟩
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- Standard treatment for locally advanced head and neck squamous cell carcinoma (LAHNSCC) consists mainly of concurrent chemoradiation (CCR) but induction chemotherapy (IC) by docetaxel-cisplatin-fluorouracil (TPF), followed by CCR, is a strong option. Comparative trials suggest that IC and CCR are equivalent, and some trials suggest superiority of IC, whereas none shows inferiority. IC might have less interest in oropharyngeal cancer (more often linked to HPV infection). When functional laryngeal preservation is the patient's priority, essays strongly suggest that IC is the best treatment. There is little data about a less toxic regimen of IC, but several schemes are promising and need to be developed. An early selection of responders to IC by metabolic imaging must be considered. Intensification attempts with cetuximab were too toxic and unsafe, but trials with immunotherapy are ongoing to enhance TPF efficacy. After IC, CCR either with cetuximab or cisplatin seems to be equally effective.
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
Cetuximab
Laryngectomy
Docetaxel
03 medical and health sciences
0302 clinical medicine
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
Humans
Medicine
030223 otorhinolaryngology
Neoplasm Staging
Randomized Controlled Trials as Topic
Squamous Cell Carcinoma of Head and Neck
business.industry
Standard treatment
Head and neck cancer
Induction chemotherapy
Cancer
Chemoradiotherapy
Induction Chemotherapy
Immunotherapy
medicine.disease
Head and neck squamous-cell carcinoma
Progression-Free Survival
3. Good health
Regimen
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Fluorouracil
Cisplatin
Larynx
Oral Surgery
business
Organ Sparing Treatments
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 13688375
- Database :
- OpenAIRE
- Journal :
- Oral Oncology, Oral Oncology, Elsevier, 2019, 95, pp.164-169. ⟨10.1016/j.oraloncology.2019.06.015⟩
- Accession number :
- edsair.doi.dedup.....669c6a1a7f945c158a39a5ece29aee20