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Bile reflux in patients with nerd is associated with more severe heartburn and lower values of mean nocturnal baseline impedance and chemical clearance

Authors :
Nicola de Bortoli
C. Prakash Gyawali
Eleonora Vichi
Vincenzo Savarino
Edoardo Savarino
Marzio Frazzoni
Elisa Marabotto
Pierfrancesco Visaggi
Massimo Bellini
Santino Marchi
Salvatore Tolone
Roberto Penagini
Leonardo Frazzoni
de Bortoli, N.
Gyawali, C. P.
Frazzoni, M.
Tolone, S.
Frazzoni, L.
Vichi, E.
Visaggi, P.
Bellini, M.
Marabotto, E.
Penagini, R.
Savarino, V.
Marchi, S.
Savarino, E. V.
Publication Year :
2020

Abstract

Background: Mean nocturnal baseline impedance (MNBI) and postreflux swallow-induced peristaltic wave (PSPW) index are novel impedance-based markers of reflux, but the effect of bile reflux on these metrics is unknown. The aim of this study was to evaluate bile reflux, MNBI, and PSPW index in patients with endoscopy-negative GERD partially responsive to PPI therapy. Methods: All patients underwent off-PPI endoscopy, esophageal manometry, multichannel intraluminal impedance pH (MII-pH), and bile reflux monitoring. Abnormal esophageal acid exposure time (AET) was required for inclusion. Symptom intensity (using 10-cm visual analog scales), and conventional and novel MII-pH metrics were compared between patients with and without abnormal bile reflux. Key Results: We evaluated 42 NERD patients (29 males, mean age: 53.4±13.years), mean AET 6.1±2%, of which 21 had abnormal bile reflux (Group A, 10.2±4.9%), and 21 had normal bile reflux (Group B, 0.4±0.1%, P&nbsp

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....66a71703711c3d5c89dda01fc392337f