Additional file 1: of Xenotropic and polytropic retrovirus receptor 1 (XPR1) promotes progression of tongue squamous cell carcinoma (TSCC) via activation of NF-ÎşB signaling

Table S1. Clinicopathological characteristics of 128 patient samples. Table S2. Univariate and multivariate analysis of factors associated with overall survival in 128 TSCC patients. Figure S1. (A) The XPR1 mRNA expression of TSCC tissues compared to normal controls by analyzing data set from The Cancer Genome Atlas (TCGA). (B) High expression of XPR1 significantly predicted poorer overall survival in patients with HNSC in TCGA data, as indicated by the human protein atlas program ( https://www.proteinatlas.org/ ). (C) Number of specimen in different XPR1 staining score. Figure S2. (A and B) Flow cytometry analysis of annexin V-FITC/PI staining to determine the basal apoptosis rate of SCC-25 and CAL-27 cells with or without XPR1 overexpression (A) or knockdown (B). Figure S3. (A) Relative NF-ÎşB reporter assay in indicated cells. (B) Kaplan-Meier overall survival curve for patients with p65-cytoplasma versus p65-nuclear. (PDF 659 kb)