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Characterization of the Progression Pattern in Retinopathy of Prematurity Subtypes
- Source :
- Ophthalmology. Retina. 4(3)
- Publication Year :
- 2019
-
Abstract
- Purpose To evaluate differences in the progression pattern among subtypes of retinopathy of prematurity (ROP). Design Retrospective cohort study. Participants Premature infants screened for ROP. Methods Medical records of 578 premature infants who were screened at the neonatal intensive care unit from September 2009 through March 2016 were reviewed. We matched for the number of patients, gestational age at birth, and postmenstrual age at the first examination between infants with spontaneously regressed ROP and those with treated ROP. A total of 133 premature infants who were born before 27 weeks’ gestation were included. Main Outcome Measures The mean age at onset of any ROP and the duration from the initial examination to onset were compared between infants with regressed ROP and those with treated ROP. The mean age at treatment and the duration from onset to treatment were compared between infants with type 1 ROP and those with aggressive posterior ROP (AP-ROP). Data were analyzed for 1 randomly selected eye for each infant. Results Of 133 premature infants with any ROP, 67 regressed spontaneously, 43 demonstrated type 1 ROP, and 23 demonstrated AP-ROP. Individual trajectories of ROP progression over time showed that AP-ROP progressed through the stages in a steep linear manner in most cases. In contrast, the type 1 ROP and regressed ROP developed in a slower, stepwise manner. Conclusions In infants with ROP, the disease trajectories across ROP stages are different based on the ROP subtype, despite postmenstrual age at onset being comparable across subtypes. Our findings could be useful for managing follow-up screening.
- Subjects :
- Male
congenital, hereditary, and neonatal diseases and abnormalities
Pediatrics
medicine.medical_specialty
Neonatal intensive care unit
genetic structures
Gestational Age
Retina
03 medical and health sciences
0302 clinical medicine
Ophthalmology
Intensive Care Units, Neonatal
medicine
Humans
Retinopathy of Prematurity
030304 developmental biology
Retrospective Studies
0303 health sciences
business.industry
Medical record
Outcome measures
Postmenstrual Age
Infant, Newborn
Gestational age
Retrospective cohort study
Retinopathy of prematurity
medicine.disease
eye diseases
030221 ophthalmology & optometry
Disease Progression
Gestation
Female
sense organs
business
Subjects
Details
- ISSN :
- 24686530
- Volume :
- 4
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Ophthalmology. Retina
- Accession number :
- edsair.doi.dedup.....66d8fdf9c55e507bed363b8d8f604381