Immunosuppressive Sesquiterpenes fromBuddleja daviddi

Six new sesquiterpenes, 2,6(12),10-humulatrien-7 β-ol-1-one ( 1), 2 α-acetoxy-5 α-methoxy-enantio-caryophylla-8(15)-en-3-one ( 2), 2 α-acetoxy-5 α-hydroxy-enantio-caryophylla-8(15)-en-3-one ( 3), 2 α-acetoxy-4 β,5 α-hydroxy-enantio-caryophylla-8(15)-en-3-one ( 4), 2 α-acetoxy-4 β,5 β-hydroxy-enantio-caryophylla-8(15)-en-3-one ( 5), 2 β-acetoxy-4-caryophyllen-8 β-ol-3-one ( 6), and nineteen known compounds were isolated from the ethanol extract of BUDDLEJA DAVIDDI. The structures were elucidated by spectroscopic methods. Compounds 8- 11, 14, 16, 17, and 20 showed significant immunosuppressive activities, and 8- 11 and 14 were cytotoxic on HeLa and L929 cell lines.