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B cells and herpesviruses: a model of lymphoproliferation
- Publication Year :
- 2007
-
Abstract
- Unlike alpha- and beta-herpesviruses, human gamma-herpesviruses, including the Epstein-Barr virus (EBV) and the human herpesvirus-8 (HHV-8), are B lymphotropic viruses. Primary infection with EBV, in otherwise healthy subjects, causes a benign lymphoproliferative syndrome, the mononucleosis syndrome. However, several epidemiologic and biologic studies have shown a pathogenetic role of EBV in the development of human B cell lymphomas, both in immunocompetent and in immunosuppressed individuals. HHV-8 is the necessary etiologic agent of a lymph vascular tumor, the Kaposi sarcoma, but it is also implicated in the pathogenesis of rare B cell lymphoproliferative disorders, mainly occurring in the setting of immunosuppression. The aim of this review is to provide an updated description of the different strategies used by these two herpesviruses to influence B cell fate decisions. Both EBV and HHV-8 have evolved specific mechanisms in order to: (1) interact with the B cell developmental machinery; (2) allow infected B cells to escape from the control of the immune system; (3) affect the B cell cycle checkpoints; (4) mimic and influence B cellular proliferation and differentiation pathways. Understanding the mechanisms of herpesvirus induced B cell lymphoproliferation will provide the basis for novel treatment approaches in patients with EBV and HHV-8 related lymphomas.
- Subjects :
- Herpesvirus 4, Human
Lymphoma, B-Cell
viruses
medicine.medical_treatment
Immunology
Lymphoproliferative disorders
Biology
Virus
Immune system
Antigen
medicine
Immunology and Allergy
Humans
Antigens, Viral
B cell
Cell Proliferation
B-Lymphocytes
Receptors, Notch
Cell growth
virus diseases
Immunosuppression
Herpesviridae Infections
medicine.disease
Lymphoproliferative Disorders
Lymphoma
Wnt Proteins
medicine.anatomical_structure
Herpesvirus 8, Human
EBV
Herpesvirus
HHV-8
Lymphoproliferation
Signal Transduction
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....671d8e62051c471e3fceeef58d390d59