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Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration
- Source :
- Journal of Parkinson's disease. 3(4)
- Publication Year :
- 2013
-
Abstract
- The pathogenesis of many neurodegenerative disorders arises in association with the misfolding and accumulation of a wide variety of proteins. Much emphasis has been placed on understanding the nature of these protein accumulations, including their composition, the process by which they are formed and the physiological impact they impose at cellular and, ultimately, organismal levels. Alpha-synuclein (ASYN) is the major component of protein inclusions known as Lewy bodies and Lewy neurites, which are the typical pathological hallmarks in disorders referred to as synucleinopathies. In addition, mutations or multiplications in the gene encoding for ASYN have also been shown to cause familial cases of PD, the most common synucleinopathy. Although the precise function of ASYN remains unclear, it appears to be involved in a vast array of cellular processes. Here, we review, in depth, a spectrum of cellular and molecular mechanisms that have been implicated in synucleinopathies. Importantly, detailed understanding of the biology/pathobiology of ASYN may enable the development of novel avenues for diagnosis and/or therapeutic intervention in synucleinopathies.
- Subjects :
- Lewy Body Disease
Parkinson's disease
Biology
Endoplasmic Reticulum
Synaptic Transmission
Pathogenesis
03 medical and health sciences
Cellular and Molecular Neuroscience
chemistry.chemical_compound
0302 clinical medicine
beta-Synuclein
gamma-Synuclein
medicine
Pure Autonomic Failure
Animals
Humans
Phosphorylation
Pathological
030304 developmental biology
Synucleinopathies
Alpha-synuclein
0303 health sciences
Lewy body
Neurodegeneration
Ubiquitination
Parkinson Disease
Multiple System Atrophy
medicine.disease
Ubiquitinated Proteins
3. Good health
chemistry
alpha-Synuclein
Lewy Bodies
Neurology (clinical)
Neuroscience
030217 neurology & neurosurgery
Function (biology)
Subjects
Details
- ISSN :
- 1877718X
- Volume :
- 3
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Parkinson's disease
- Accession number :
- edsair.doi.dedup.....673f5aa5392d6896eb6280dbebc17ced