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Cleaved Form of Osteopontin in Urine as a Clinical Marker of Lupus Nephritis
- Source :
- PLoS ONE, PLoS ONE, Vol 11, Iss 12, p e0167141 (2016)
- Publication Year :
- 2016
-
Abstract
- We assessed the utility of two forms of osteopontin (OPN), OPN full and its cleaved form (OPN N-half), in plasma and urine as markers of disease activity in lupus nephritis (LN). Samples were collected from patients with systemic lupus erythematosus (SLE) (LN: N = 29, non- LN: N = 27), IgA nephropathy (IgAN) (N = 14), minimal change nephrotic syndrome (MCNS) (N = 5), diabetic nephropathy (DN) (N = 14) and healthy volunteers (HC) (N = 17). While there was no significant difference in urine OPN full concentration between groups, urine OPN N-half concentration was significantly higher in patients with LN than HC (p < 0.05). Moreover, urine OPN N-half was higher in LN patients with overt proteinuria (urine protein/ creatinine ratio: P/C > 0.5) than LN patients with minimal proteinuria (P/C < 0.5, p < 0.0001), and also higher than in DN patients with overt proteinuria (P/C > 0.5, p < 0.01). Urine thrombin activity correlated with urine OPN N-half concentration (p < 0.0001), but not with urine OPN full concentration. These results suggest that urine OPN N-half concentration reflects renal inflammation. Thus, urine OPN N-half may be a novel disease activity marker for LN.
- Subjects :
- 0301 basic medicine
Male
Physiology
Lupus nephritis
lcsh:Medicine
Urine
Pathology and Laboratory Medicine
Biochemistry
White Blood Cells
0302 clinical medicine
Endocrinology
Animal Cells
Medicine and Health Sciences
Lupus Erythematosus, Systemic
Diabetic Nephropathies
Osteopontin
lcsh:Science
Aged, 80 and over
Multidisciplinary
Proteinuria
biology
T Cells
Thrombin
Glomerulonephritis
Middle Aged
Lupus Nephritis
Body Fluids
Creatinine
Female
medicine.symptom
Anatomy
Cellular Types
Research Article
Adult
medicine.medical_specialty
Endocrine Disorders
Nephrosis
Inflammatory Diseases
Immune Cells
Immunology
Systemic Lupus Erythematosus
Nephropathy
Autoimmune Diseases
03 medical and health sciences
Young Adult
Signs and Symptoms
stomatognathic system
Rheumatology
Diagnostic Medicine
Internal medicine
medicine
Diabetes Mellitus
Humans
Aged
030203 arthritis & rheumatology
Lupus erythematosus
Blood Cells
Lupus Erythematosus
business.industry
Nephrosis, Lipoid
lcsh:R
Biology and Life Sciences
Proteins
Glomerulonephritis, IGA
Cell Biology
medicine.disease
Peptide Fragments
030104 developmental biology
Metabolic Disorders
biology.protein
lcsh:Q
Clinical Immunology
Clinical Medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....675f0a1e89aadba531471b17dee5076f