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SIR2-induced inviability is suppressed by histone H4 overexpression
- Publication Year :
- 2002
-
Abstract
- We have identified histone H4 as a high-expression suppressor of Sir2-induced inviability in yeast cells. Overexpression of histone H3 does not suppress Sir2-induced lethality, nor does overexpression of histone H4 alleles associated with silencing defects. These results suggest a direct and specific interaction between Sir2 and H4 in the silencing mechanism.
- Subjects :
- Genetics
Histone deacetylase 5
Histone deacetylase 2
Lysine
Saccharomyces cerevisiae
Biology
Molecular biology
Histone Deacetylases
Histone H4
Histones
Histone H3
enzymes and coenzymes (carbohydrates)
Sirtuin 2
Suppression, Genetic
Histone H1
Histone methyltransferase
Histone H2A
Histone methylation
Sirtuins
Genes, Lethal
Silent Information Regulator Proteins, Saccharomyces cerevisiae
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....6789229c08a7429dc679442f59b6ed34