Back to Search Start Over

Associations between maternal long-chain polyunsaturated fatty acid concentrations and child cognition at 7 years of age:the MEFAB birth cohort

Associations between maternal long-chain polyunsaturated fatty acid concentrations and child cognition at 7 years of age:the MEFAB birth cohort

Authors :
Roger W. L. Godschalk
O. van de Rest
Marij Gielen
Maurice P. Zeegers
Elske M. Brouwer-Brolsma
R.H.M. de Groot
Farmacologie en Toxicologie
RS: NUTRIM - R3 - Respiratory & Age-related Health
RS: NUTRIM - R4 - Gene-environment interaction
Complexe Genetica
RS-Research Line Fostering Effective, Efficient and Enjoyable Learning (FEEEL) (part of WO program)
Department FEEEL
Source :
Brouwer-Brolsma, E, Van de Rest, O, Godschalk, R, Zeegers, M, Gielen, M & De Groot, R 2017, ' Associations between maternal long-chain polyunsaturated fatty acid concentrations and child cognition at 7 years of age : the MEFAB birth cohort ', Prostaglandins, Leukotrienes, & Essential Fatty Acids, vol. 126, pp. 92-97 . https://doi.org/10.1016/j.plefa.2017.09.012, Prostaglandins Leukotrienes and Essential Fatty Acids, 126, 92-97, Prostaglandins Leukotrienes and Essential Fatty Acids, 126, 92-97. ELSEVIER SCI LTD, Prostaglandins Leukotrienes and Essential Fatty Acids 126 (2017), Prostaglandins, Leukotrienes, & Essential Fatty Acids, 126, 92-97. Churchill Livingstone
Publication Year :
2017

Abstract

Introduction: Concentrations of the fish fatty acids EPA and DHA are low among Dutch women of reproductive age. As the human brain incorporates high concentrations of these fatty acids in utero, particularly during third trimester of gestation, these low EPA and DHA concentrations may have adverse consequences for fetal brain development and functioning.Methods: Analyses were conducted using longitudinal observational data of 292 mother-child pairs participating in the MEFAB cohort. Maternal AA, DHA, and EPA were determined in plasma phospholipids - obtained in three trimesters-by gas-liquid chromatography. Cognitive function was assessed at 7 years of age, using the Kaufman Assessment Battery for Children, resulting in three main outcome parameters: sequential processing (short-term memory), simultaneous processing (problem-solving skills), and the mental processing composite score. Spline regression and linear regression analyses were used to analyse the data, while adjusting for potential relevant covariates.Results: Only 2% of the children performed more than one SD below the mental processing composite norm score. Children with lower test scores ( = 25%). Fully-adjusted linear regression models did not show associations of maternal AA, DHA, or EPA status during any of the pregnancy trimesters with childhood sequential and simultaneous processing.Conclusion: Maternal fatty acid status during pregnancy was not associated with cognitive performance in Dutch children at age 7.

Details

Language :
English
ISSN :
09523278
Database :
OpenAIRE
Journal :
Brouwer-Brolsma, E, Van de Rest, O, Godschalk, R, Zeegers, M, Gielen, M & De Groot, R 2017, ' Associations between maternal long-chain polyunsaturated fatty acid concentrations and child cognition at 7 years of age : the MEFAB birth cohort ', Prostaglandins, Leukotrienes, & Essential Fatty Acids, vol. 126, pp. 92-97 . https://doi.org/10.1016/j.plefa.2017.09.012, Prostaglandins Leukotrienes and Essential Fatty Acids, 126, 92-97, Prostaglandins Leukotrienes and Essential Fatty Acids, 126, 92-97. ELSEVIER SCI LTD, Prostaglandins Leukotrienes and Essential Fatty Acids 126 (2017), Prostaglandins, Leukotrienes, & Essential Fatty Acids, 126, 92-97. Churchill Livingstone
Accession number :
edsair.doi.dedup.....67b0a1bea42392e064a2853c6f582d9a
Full Text :
https://doi.org/10.1016/j.plefa.2017.09.012