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Associations between maternal long-chain polyunsaturated fatty acid concentrations and child cognition at 7 years of age:the MEFAB birth cohort
Associations between maternal long-chain polyunsaturated fatty acid concentrations and child cognition at 7 years of age:the MEFAB birth cohort
- Source :
- Brouwer-Brolsma, E, Van de Rest, O, Godschalk, R, Zeegers, M, Gielen, M & De Groot, R 2017, ' Associations between maternal long-chain polyunsaturated fatty acid concentrations and child cognition at 7 years of age : the MEFAB birth cohort ', Prostaglandins, Leukotrienes, & Essential Fatty Acids, vol. 126, pp. 92-97 . https://doi.org/10.1016/j.plefa.2017.09.012, Prostaglandins Leukotrienes and Essential Fatty Acids, 126, 92-97, Prostaglandins Leukotrienes and Essential Fatty Acids, 126, 92-97. ELSEVIER SCI LTD, Prostaglandins Leukotrienes and Essential Fatty Acids 126 (2017), Prostaglandins, Leukotrienes, & Essential Fatty Acids, 126, 92-97. Churchill Livingstone
- Publication Year :
- 2017
-
Abstract
- Introduction: Concentrations of the fish fatty acids EPA and DHA are low among Dutch women of reproductive age. As the human brain incorporates high concentrations of these fatty acids in utero, particularly during third trimester of gestation, these low EPA and DHA concentrations may have adverse consequences for fetal brain development and functioning.Methods: Analyses were conducted using longitudinal observational data of 292 mother-child pairs participating in the MEFAB cohort. Maternal AA, DHA, and EPA were determined in plasma phospholipids - obtained in three trimesters-by gas-liquid chromatography. Cognitive function was assessed at 7 years of age, using the Kaufman Assessment Battery for Children, resulting in three main outcome parameters: sequential processing (short-term memory), simultaneous processing (problem-solving skills), and the mental processing composite score. Spline regression and linear regression analyses were used to analyse the data, while adjusting for potential relevant covariates.Results: Only 2% of the children performed more than one SD below the mental processing composite norm score. Children with lower test scores ( = 25%). Fully-adjusted linear regression models did not show associations of maternal AA, DHA, or EPA status during any of the pregnancy trimesters with childhood sequential and simultaneous processing.Conclusion: Maternal fatty acid status during pregnancy was not associated with cognitive performance in Dutch children at age 7.
- Subjects :
- 0301 basic medicine
Pediatrics
Clinical Biochemistry
Physiology
Maternal
SUPPLEMENTATION
Child Development
Cognition
Medicine
Child
Cognitive performance
cognitive performance
Phospholipids
FISH-OIL
chemistry.chemical_classification
Arachidonic Acid
Kaufman Assessment Battery for Children
Breast Feeding
Memory, Short-Term
PREGNANCY
Docosahexaenoic acid
Child, Preschool
Cohort
Fatty Acids, Unsaturated
Gestation
Female
TERM INFANTS
Polyunsaturated fatty acid
Adult
medicine.medical_specialty
Docosahexaenoic Acids
Offspring
NEURODEVELOPMENT
03 medical and health sciences
Humans
EXPOSURE
ACCRETION
LCPUFA
VLAG
childhood
Global Nutrition
Pregnancy
Wereldvoeding
030109 nutrition & dietetics
offspring
business.industry
Fatty acid
Cell Biology
DOCOSAHEXAENOIC ACID
medicine.disease
Childhood
DHA STATUS
N-3
maternal
chemistry
business
Subjects
Details
- Language :
- English
- ISSN :
- 09523278
- Database :
- OpenAIRE
- Journal :
- Brouwer-Brolsma, E, Van de Rest, O, Godschalk, R, Zeegers, M, Gielen, M & De Groot, R 2017, ' Associations between maternal long-chain polyunsaturated fatty acid concentrations and child cognition at 7 years of age : the MEFAB birth cohort ', Prostaglandins, Leukotrienes, & Essential Fatty Acids, vol. 126, pp. 92-97 . https://doi.org/10.1016/j.plefa.2017.09.012, Prostaglandins Leukotrienes and Essential Fatty Acids, 126, 92-97, Prostaglandins Leukotrienes and Essential Fatty Acids, 126, 92-97. ELSEVIER SCI LTD, Prostaglandins Leukotrienes and Essential Fatty Acids 126 (2017), Prostaglandins, Leukotrienes, & Essential Fatty Acids, 126, 92-97. Churchill Livingstone
- Accession number :
- edsair.doi.dedup.....67b0a1bea42392e064a2853c6f582d9a
- Full Text :
- https://doi.org/10.1016/j.plefa.2017.09.012