Back to Search
Start Over
Efficacy of Reboxetine in the Treatment of Attention-Deficit/Hyperactivity Disorder in Boys With Intolerance to Methylphenidate
- Source :
- Clinical Neuropharmacology. 32:179-182
- Publication Year :
- 2009
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2009.
-
Abstract
- Objective Attention-deficit/hyperactivity disorder (ADHD) is the most common neurobehavioral disorder of childhood. Principal treatment options for ADHD today include the psychostimulants, mainly methylphenidate (MPH). However, approximately 30% to 50% of children and adults with ADHD either do not respond to or do not tolerate treatment with stimulants. In this 8-week open-label, MPH-controlled, parallel group design study, we investigate the efficacy of reboxetine, a new selective norepinephrine reuptake inhibitor, in the treatment of boys with ADHD with a history of intolerance to MPH therapy. Method Twenty-seven outpatient boys, aged 6 to 16 years, diagnosed with ADHD, participated in the study. Those with a history of intolerance to MPH therapy were assigned to treatment with reboxetine (2-8 mg/d), and the rest were assigned to treatment with MPH (10-20 mg/d) as the control group. The primary outcome measure for this study was the change in rating scores on the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, ADHD Scale (DAS) that was assessed at baseline and at 8 weeks. Results At the end of 8 weeks, both reboxetine and MPH treatment regimens resulted in significant improvement in ADHD symptoms. The change in the reduction in the total DAS score and the DAS subscale scores between the reboxetine group and the MPH group was not statistically significant in any of the scores. Conclusions Although preliminary, results of this study indicate that the use of reboxetine, a new selective norepinephrine reuptake inhibitor, in the treatment of ADHD could increase treatment options available for children who have shown intolerance or who are unresponsive to MPH.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Patient Dropouts
Adolescent
Psychometrics
Morpholines
law.invention
Reboxetine
Primary outcome
Dopamine Uptake Inhibitors
Randomized controlled trial
law
mental disorders
medicine
Humans
Attention deficit hyperactivity disorder
Pharmacology (medical)
Adhd symptoms
Child
Psychiatry
Psychiatric Status Rating Scales
Pharmacology
Adrenergic Uptake Inhibitors
Methylphenidate
medicine.disease
Treatment Outcome
Attention Deficit Disorder with Hyperactivity
Neurology (clinical)
Open label
Psychology
human activities
medicine.drug
Subjects
Details
- ISSN :
- 03625664
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Clinical Neuropharmacology
- Accession number :
- edsair.doi.dedup.....67cf61d63e6b83a52b77a8b2818414eb