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Jarisch-Herxheimer Reaction After Cephalosporin Administration in Syphilis
Jarisch-Herxheimer Reaction After Cephalosporin Administration in Syphilis
- Source :
- Cureus
- Publication Year :
- 2021
- Publisher :
- Cureus, Inc., 2021.
-
Abstract
- The Jarisch-Herxheimer reaction (JHR) is a well-described entity most commonly occurring after the treatment of syphilis with penicillin. Patients often experience flu-like symptoms, in addition to worsening of cutaneous manifestations of syphilis. Severe reactions are uncommon but may include signs of exaggerated systemic inflammatory response. We report a case of a 33-year-old male with secondary syphilis who was treated with ceftriaxone and subsequently developed fluid-refractory hypotension requiring vasopressor administration and intensive care unit admission. To our knowledge, this is the first report of severe hypotension as a result of JHR in a patient with syphilis who was treated with cephalosporin antibiotics.
- Subjects :
- hypotension
medicine.medical_specialty
jarisch-herxheimer
medicine.drug_class
cephalosporin
Cephalosporin
syphilis
Infectious Disease
Secondary syphilis
030204 cardiovascular system & hematology
law.invention
03 medical and health sciences
0302 clinical medicine
law
Internal medicine
Internal Medicine
Medicine
Cephalosporin Antibiotic
business.industry
General Engineering
Jarisch–Herxheimer reaction
medicine.disease
Intensive care unit
Penicillin
Ceftriaxone
Syphilis
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 21688184
- Database :
- OpenAIRE
- Journal :
- Cureus
- Accession number :
- edsair.doi.dedup.....67f8c01b5589afc2e61ce735a3e7bc36
- Full Text :
- https://doi.org/10.7759/cureus.12750