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Jarisch-Herxheimer Reaction After Cephalosporin Administration in Syphilis

Jarisch-Herxheimer Reaction After Cephalosporin Administration in Syphilis

Authors :
Jennifer R Olges
Caitlin McKenzie
Source :
Cureus
Publication Year :
2021
Publisher :
Cureus, Inc., 2021.

Abstract

The Jarisch-Herxheimer reaction (JHR) is a well-described entity most commonly occurring after the treatment of syphilis with penicillin. Patients often experience flu-like symptoms, in addition to worsening of cutaneous manifestations of syphilis. Severe reactions are uncommon but may include signs of exaggerated systemic inflammatory response. We report a case of a 33-year-old male with secondary syphilis who was treated with ceftriaxone and subsequently developed fluid-refractory hypotension requiring vasopressor administration and intensive care unit admission. To our knowledge, this is the first report of severe hypotension as a result of JHR in a patient with syphilis who was treated with cephalosporin antibiotics.

Details

ISSN :
21688184
Database :
OpenAIRE
Journal :
Cureus
Accession number :
edsair.doi.dedup.....67f8c01b5589afc2e61ce735a3e7bc36
Full Text :
https://doi.org/10.7759/cureus.12750