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Bufospirostenin A and Bufogargarizin C, Steroids with Rearranged Skeletons from the Toad Bufo bufo gargarizans

Authors :
Ruibo Wu
Nanhao Chen
Tong Yu
Qingfei Zheng
Hai-Yan Tian
Wen-Cai Ye
Li-Jun Ruan
Lei Wang
Xiao-Qi Zhang
Ren-Wang Jiang
Source :
Journal of Natural Products. 80:1182-1186
Publication Year :
2017
Publisher :
American Chemical Society (ACS), 2017.

Abstract

Bufospirostenin A (1) and bufogargarizin C (2), two novel steroids with rearranged A/B rings, were isolated from the toad Bufo bufo gargarizans. Compound 1 represents the first spirostanol found in animals. Compound 2 is an unusual bufadienolide with a cycloheptatriene B ring. Their structures were elucidated by spectroscopic analysis, single crystal X-ray diffraction analysis, and computational calculations.

Details

ISSN :
15206025 and 01633864
Volume :
80
Database :
OpenAIRE
Journal :
Journal of Natural Products
Accession number :
edsair.doi.dedup.....67f9f00febef12a4591830e39edc9584
Full Text :
https://doi.org/10.1021/acs.jnatprod.6b01018