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Neuronal erythropoietin overexpression protects mice against age-related hearing loss (presbycusis)
- Publication Year :
- 2015
- Publisher :
- Elsevier, 2015.
-
Abstract
- So far, typical causes of presbycusis such as degeneration of hair cells and/or primary auditory (spiral ganglion) neurons cannot be treated. Because erythropoietin's (Epo) neuroprotective potential has been shown previously, we determined hearing thresholds of juvenile and aged mice overexpressing Epo in neuronal tissues. Behavioral audiometry revealed in contrast to 5 months of age, that 11-month-old Epo-transgenic mice had up to 35 dB lower hearing thresholds between 1.4 and 32 kHz, and at the highest frequencies (50-80 kHz), thresholds could be obtained in aged Epo-transgenic only but not anymore in old C57BL6 control mice. Click-evoked auditory brainstem response showed similar results. Numbers of spiral ganglion neurons in aged C57BL6 but not Epo-transgenic mice were dramatically reduced mainly in the basal turn, the location of high frequencies. In addition, there was a tendency to better preservation of inner and outer hair cells in Epo-transgenic mice. Hence, Epo's known neuroprotective action effectively suppresses the loss of spiral ganglion cells and probably also hair cells and, thus, development of presbycusis in mice.
- Subjects :
- Aging
Excitotoxicity
Gene Expression
Presbycusis
10045 Clinic for Otorhinolaryngology
2717 Geriatrics and Gerontology
medicine.disease_cause
1309 Developmental Biology
Erythropoietin/genetics/physiology
Hair Cells, Auditory/pathology
medicine.diagnostic_test
Spiral Ganglion/cytology/pathology
General Neuroscience
2800 General Neuroscience
Gene Expression Regulation, Developmental
10081 Institute of Veterinary Physiology
Neuroprotection
Cochlea
2728 Neurology (clinical)
medicine.anatomical_structure
Neuroprotective Agents
10076 Center for Integrative Human Physiology
Evoked Potentials, Auditory/physiology
Evoked Potentials, Auditory
Spiral ganglion
Spiral Ganglion
medicine.drug
medicine.medical_specialty
Age-related hearing loss (ARHL)
610 Medicine & health
Mice, Transgenic
Presbycusis/genetics/pathology/prevention & control
Biology
ABR
1302 Aging
Internal medicine
Hair Cells, Auditory
medicine
otorhinolaryngologic diseases
Animals
Erythropoietin
purl.org/pe-repo/ocde/ford#3.01.04 [https]
medicine.disease
Mice, Inbred C57BL
Gene Expression/genetics
purl.org/pe-repo/ocde/ford#1.06.09 [https]
Auditory brainstem response
Endocrinology
Nerve Degeneration
Neurology (clinical)
sense organs
Geriatrics and Gerontology
Audiometry
purl.org/pe-repo/ocde/ford#3.02.26 [https]
Neuroscience
Gene Expression Regulation, Developmental/genetics
Developmental Biology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....680aa0168a8aebfbe133f60fc1a2d277