Supplemental Figure 1 from SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer

Western blot analysis of protein levels and phosphorylated forms of MET, EGFR, MAPK, AKT, GLI1 and beta actin in protein lysates from tumors harvested from nude mice treated with the indicated drugs.