Back to Search
Start Over
Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis
- Source :
- Erdem, H, Cag, Y, Ozturk-Engin, D, Defres, S, Kaya, S, Larsen, L, Poljak, M, Barsic, B, Argemi, X, Sørensen, S M, Bohr, A L, Tattevin, P, Gunst, J D, Baštáková, L, Jereb, M, Johansen, I S, Karabay, O, Pekok, A U, Sipahi, O R, Chehri, M, Beraud, G, Shehata, G, Del Vecchio, R F, Maresca, M, Karsen, H, Sengoz, G, Sunbul, M, Yilmaz, G, Yilmaz, H, Sharif-Yakan, A, Kanj, S S, Parlak, E, Pehlivanoglu, F, Korkmaz, F, Komur, S, Kose, S, Ulug, M, Bolukcu, S, Coskuner, S A, Ince, N, Akkoyunlu, Y, Halac, G, Sahin-Horasan, E, Tireli, H, Kilicoglu, G, Al-Mahdawi, A, Nemli, S A, Inan, A, Senbayrak, S, Stahl, J P & Vahaboglu, H 2015, ' Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis ', Antimicrobial Agents and Chemotherapy, vol. 59, no. 6, pp. 3084-3089 . https://doi.org/10.1128/AAC.05016-14, Erdem, H, Cag, Y, Ozturk-Engin, D, Defres, S, Kaya, S, Larsen, L, Poljak, M, Barsic, B, Argemi, X, Sørensen, S M, Bohr, A L, Tattevin, P, Damsgaard Gunst, J, Baštáková, L, Jereb, M, Johansen, I S, Karabay, O, Pekok, A U, Sipahi, O R, Chehri, M, Beraud, G, Shehata, G, Del Vecchio, R F, Maresca, M, Karsen, H, Sengoz, G, Sunbul, M, Yilmaz, G, Yilmaz, H, Sharif-Yakan, A, Kanj, S S, Parlak, E, Pehlivanoglu, F, Korkmaz, F, Komur, S, Kose, S, Ulug, M, Bolukcu, S, Coskuner, S A, Ince, N, Akkoyunlu, Y, Halac, G, Sahin-Horasan, E, Tireli, H, Kilicoglu, G, Al-Mahdawi, A, Nemli, S A, Inan, A, Senbayrak, S, Stahl, J P & Vahaboglu, H 2015, ' Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis ', Antimicrobial Agents and Chemotherapy, vol. 59, no. 6, pp. 3084-9 . https://doi.org/10.1128/AAC.05016-14, Erdem, H, Cag, Y, Ozturk-Engin, D, Defres, S, Kaya, S, Larsen, L, Poljak, M, Barsic, B, Argemi, X, Sørensen, S M, Bohr, A L, Tattevin, P, Gunst, J D, Baštáková, L, Jereb, M, Somuncu Johansen, I, Karabay, O, Pekok, A U, Sipahi, O R, Chehri, M, Beraud, G, Shehata, G, Fontana Del Vecchio, R, Maresca, M, Karsen, H, Sengoz, G, Sunbul, M, Yilmaz, G, Yilmaz, H, Sharif-Yakan, A, Kanj, S, Parlak, E, Pehlivanoglu, F, Korkmaz, F, Komur, S, Kose, S, Ulug, M, Bolukcu, S, Coskuner, S A, Ince, N, Akkoyunlu, Y, Halac, G, Sahin-Horasan, E, Tireli, H, Kilicoglu, G, Al-Mahdawi, A, Nemli, S A, Inan, A, Senbayrak, S, Stahl, J P & Vahaboglu, H 2015, ' Results of a Multinational Study Suggest the Need for Rapid Diagnosis and Early Antiviral Treatment at the Onset of Herpetic Meningoencephalitis ', Antimicrobial Agents and Chemotherapy, vol. 59, no. 6, pp. 3084-3089 . https://doi.org/10.1128/AAC.05016-14
- Publication Year :
- 2015
-
Abstract
- WOS: 000358623200015<br />PubMed ID: 25779579<br />Data in the literature regarding the factors that predict unfavorable outcomes in adult herpetic meningoencephalitis (HME) cases are scarce. We conducted a multicenter study in order to provide insights into the predictors of HME outcomes, with special emphasis on the use and timing of antiviral treatment. Samples from 501 patients with molecular confirmation from cerebrospinal fluid were included from 35 referral centers in 10 countries. Four hundred thirty-eight patients were found to be eligible for the analysis. Overall, 232 (52.9%) patients experienced unfavorable outcomes, 44 died, and 188 survived, with sequelae. Age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.02 to 1.05), Glasgow Coma Scale score (OR, 0.84; 95% CI, 0.77 to 0.93), and symptomatic periods of 2 to 7 days (OR, 1.80; 95% CI, 1.16 to 2.79) and >7 days (OR, 3.75; 95% CI, 1.72 to 8.15) until the commencement of treatment predicted unfavorable outcomes. The outcome in HME patients is related to a combination of therapeutic and host factors. This study suggests that rapid diagnosis and early administration of antiviral treatment in HME patients are keys to a favorable outcome.
- Subjects :
- Adult
Male
medicine.medical_specialty
Referral
Antiviral Agents
Internal medicine
medicine
ERDEM H., CAG Y., OZTURK-ENGIN D., Defres S., KAYA S., LARSEN L., POLJAK M., BARSIC B., ARGEMI X., SORENSEN S. M. , et al., -Results of a Multinational Study Suggest the Need for Rapid Diagnosis and Early Antiviral Treatment at the Onset of Herpetic Meningoencephalitis-, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, cilt.59, ss.3084-3089, 2015
Confidence Intervals
Humans
Pharmacology (medical)
Pharmacology & Pharmacy
Antiviral treatment
Retrospective Studies
Pharmacology
business.industry
Herpetic meningoencephalitis
Glasgow Coma Scale
Retrospective cohort study
Odds ratio
Middle Aged
medicine.disease
Confidence interval
3. Good health
Surgery
Infectious Diseases
Treatment Outcome
Female
Encephalitis, Herpes Simplex
business
Encephalitis
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Erdem, H, Cag, Y, Ozturk-Engin, D, Defres, S, Kaya, S, Larsen, L, Poljak, M, Barsic, B, Argemi, X, Sørensen, S M, Bohr, A L, Tattevin, P, Gunst, J D, Baštáková, L, Jereb, M, Johansen, I S, Karabay, O, Pekok, A U, Sipahi, O R, Chehri, M, Beraud, G, Shehata, G, Del Vecchio, R F, Maresca, M, Karsen, H, Sengoz, G, Sunbul, M, Yilmaz, G, Yilmaz, H, Sharif-Yakan, A, Kanj, S S, Parlak, E, Pehlivanoglu, F, Korkmaz, F, Komur, S, Kose, S, Ulug, M, Bolukcu, S, Coskuner, S A, Ince, N, Akkoyunlu, Y, Halac, G, Sahin-Horasan, E, Tireli, H, Kilicoglu, G, Al-Mahdawi, A, Nemli, S A, Inan, A, Senbayrak, S, Stahl, J P & Vahaboglu, H 2015, ' Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis ', Antimicrobial Agents and Chemotherapy, vol. 59, no. 6, pp. 3084-3089 . https://doi.org/10.1128/AAC.05016-14, Erdem, H, Cag, Y, Ozturk-Engin, D, Defres, S, Kaya, S, Larsen, L, Poljak, M, Barsic, B, Argemi, X, Sørensen, S M, Bohr, A L, Tattevin, P, Damsgaard Gunst, J, Baštáková, L, Jereb, M, Johansen, I S, Karabay, O, Pekok, A U, Sipahi, O R, Chehri, M, Beraud, G, Shehata, G, Del Vecchio, R F, Maresca, M, Karsen, H, Sengoz, G, Sunbul, M, Yilmaz, G, Yilmaz, H, Sharif-Yakan, A, Kanj, S S, Parlak, E, Pehlivanoglu, F, Korkmaz, F, Komur, S, Kose, S, Ulug, M, Bolukcu, S, Coskuner, S A, Ince, N, Akkoyunlu, Y, Halac, G, Sahin-Horasan, E, Tireli, H, Kilicoglu, G, Al-Mahdawi, A, Nemli, S A, Inan, A, Senbayrak, S, Stahl, J P & Vahaboglu, H 2015, ' Results of a multinational study suggest the need for rapid diagnosis and early antiviral treatment at the onset of herpetic meningoencephalitis ', Antimicrobial Agents and Chemotherapy, vol. 59, no. 6, pp. 3084-9 . https://doi.org/10.1128/AAC.05016-14, Erdem, H, Cag, Y, Ozturk-Engin, D, Defres, S, Kaya, S, Larsen, L, Poljak, M, Barsic, B, Argemi, X, Sørensen, S M, Bohr, A L, Tattevin, P, Gunst, J D, Baštáková, L, Jereb, M, Somuncu Johansen, I, Karabay, O, Pekok, A U, Sipahi, O R, Chehri, M, Beraud, G, Shehata, G, Fontana Del Vecchio, R, Maresca, M, Karsen, H, Sengoz, G, Sunbul, M, Yilmaz, G, Yilmaz, H, Sharif-Yakan, A, Kanj, S, Parlak, E, Pehlivanoglu, F, Korkmaz, F, Komur, S, Kose, S, Ulug, M, Bolukcu, S, Coskuner, S A, Ince, N, Akkoyunlu, Y, Halac, G, Sahin-Horasan, E, Tireli, H, Kilicoglu, G, Al-Mahdawi, A, Nemli, S A, Inan, A, Senbayrak, S, Stahl, J P & Vahaboglu, H 2015, ' Results of a Multinational Study Suggest the Need for Rapid Diagnosis and Early Antiviral Treatment at the Onset of Herpetic Meningoencephalitis ', Antimicrobial Agents and Chemotherapy, vol. 59, no. 6, pp. 3084-3089 . https://doi.org/10.1128/AAC.05016-14
- Accession number :
- edsair.doi.dedup.....681cc54040f9a0d49cdddf98390fddeb
- Full Text :
- https://doi.org/10.1128/AAC.05016-14