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Age-Specific Reference Ranges of Prostate-Specific Antigen among Saudi Men as a Representation of the Arab Population
- Source :
- Medical Principles and Practice. 28:242-246
- Publication Year :
- 2019
- Publisher :
- S. Karger AG, 2019.
-
Abstract
- Objective: To describe the reference ranges of serum prostate-specific antigen (PSA) in Saudi men. Materials/Subjects and Methods: Saudi males, aged 30 and above, were invited to participate in the study. Blood samples were taken from each subject to determine serum levels of PSA. Blood sugar levels, lipid profile, and anthropometric measurements were also obtained. Results: Our cohort consisted of 7,814 men; their mean PSA level was 1.24 ng/mL. The majority (90.5%) had PSA values between 0 and 2.5 ng/mL. The median PSA and the 95th percentile increased steadily with age. There was a sharp increase in the 95th percentile, from 3.8 ng/mL in men between 60 and 70 years old to 6.9 ng/mL in men over 71 years old. The 95th percentiles of PSA serum levels were lower in Saudi men than in the general population. Conclusions: PSA serum levels in Saudi men are lower than in other communities. Creating age-specific reference ranges could improve the sensitivity of the PSA tests by allowing the detection of treatable tumors in younger men if the threshold of 4.0 ng/mL is lowered. Furthermore, unnecessary biopsies among older men may be avoided if the threshold is increased.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Percentile
020205 medical informatics
Population
Saudi Arabia
Blood sugar
02 engineering and technology
urologic and male genital diseases
03 medical and health sciences
Prostate cancer
Reference Values
Internal medicine
0202 electrical engineering, electronic engineering, information engineering
medicine
Humans
Body Weights and Measures
education
Aged
Original Paper
education.field_of_study
medicine.diagnostic_test
business.industry
Age Factors
General Medicine
Middle Aged
Prostate-Specific Antigen
Anthropometry
medicine.disease
Lipids
Arabs
Prostate-specific antigen
Cross-Sectional Studies
Cohort
030101 anatomy & morphology
Lipid profile
business
Subjects
Details
- ISSN :
- 14230151 and 10117571
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Medical Principles and Practice
- Accession number :
- edsair.doi.dedup.....681f1612e95e2af71c2814113427f392
- Full Text :
- https://doi.org/10.1159/000497744