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Geographical Variations in Sex Ratio Trends over Time in Multiple Sclerosis
- Source :
- PLoS ONE, Vol 7, Iss 10, p e48078 (2012), PLOS ONE, 7(10):e48078. Public Library of Science, PLoS ONE, PLoS One, Vol. 7, no. 10, p. e48078 [1-9] (2012)
- Publication Year :
- 2012
- Publisher :
- Public Library of Science (PLoS), 2012.
-
Abstract
- Background: A female/male (F/M) ratio increase over time in multiple sclerosis (MS) patients was demonstrated in many countries around the world. So far, a direct comparison of sex ratio time-trends among MS populations from different geographical areas was not carried out. Objective: In this paper we assessed and compared sex ratio trends, over a 60-year span, in MS populations belonging to different latitudinal areas. Methods: Data of a cohort of 15,996 (F = 11,290; M = 4,706) definite MS with birth years ranging from 1930 to 1989 were extracted from the international MSBase registry and the New Zealand MS database. Gender ratios were calculated by six decades based on year of birth and were adjusted for the F/M born-alive ratio derived from the respective national registries of births. Results: Adjusted sex ratios showed a significant increase from the first to the last decade in the whole MS sample (from 2.35 to 2.73; p = 0.03) and in the subgroups belonging to the areas between 83° N and 45° N (from 1.93 to 4.55; p
- Subjects :
- Male
Gerontology
Time Factors
Non-Clinical Medicine
Databases, Factual
Epidemiology
lcsh:Medicine
Social and Behavioral Sciences
0302 clinical medicine
Sociology
5. Gender equality
Sex factors
Clinical Epidemiology
Registries
lcsh:Science
10. No inequality
Aged, 80 and over
0303 health sciences
Multidisciplinary
Geography
Regression analysis
Middle Aged
Multiple Sclerosis, Chronic Progressive
Europe
Neurology
Relapsing remitting
Cohort
Medicine
Regression Analysis
Female
Sun exposure
Sex ratio
Research Article
Adult
medicine.medical_specialty
Multiple Sclerosis
Human Geography
Sexual and Gender Issues
03 medical and health sciences
Multiple Sclerosis, Relapsing-Remitting
Sex Factors
medicine
Humans
Sex Ratio
Aged
030304 developmental biology
Health Care Policy
business.industry
Multiple sclerosis
lcsh:R
medicine.disease
Demyelinating Disorders
lcsh:Q
business
030217 neurology & neurosurgery
New Zealand
Demography
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....68477a66299c8db365f2e784b1f3a667