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Clinicopathological analysis of composite lymphoma: A two-case report and literature review
- Source :
- Open Medicine, Vol 15, Iss 1, Pp 654-658 (2020), Open Medicine
- Publication Year :
- 2020
- Publisher :
- De Gruyter, 2020.
-
Abstract
- Objective The objective of this study was to evaluate the clinicopathological features and treatment of composite lymphoma (CL) with cervical lymph node enlargement. Methods In this study, two cases of CL are presented. Biopsies of enlarged cervical lymph nodes by excision revealed two distinct types of lymphomas. The diagnoses were confirmed by routine histopathology, immunohistochemistry, in situ hybridization, polymerase chain reactions and flow cytometry. Case 1 was diagnosed with Hodgkin’s lymphoma and cytotoxic T-cell lymphoma complicated by Epstein–Barr virus infection. Case 2 was diagnosed with diffuse large B-cell lymphoma and angioimmunoblastic T-cell lymphoma. Results Case 1 received one cycle of adriamycin, bleomycin, vincristine and dacarbazine (ABVD regimen) combined with chidamide, followed by one cycle of gemcitabine and dexamethasone (GDP regimen) combined with chidamide, and then oral acyclovir. The patient achieved stable disease, but was lost to follow-up. Case 2 received eight cycles of cyclophosphamide, pirarubicin, vincristine and dexamethasone (CTOP regimen) combined with chidamide, and the patient achieved complete remission. Nine months later, relapse was confirmed. She received chidamide monotherapy for 3 months, which was then terminated. One year later, the patient underwent progressive disease and died. Conclusions CL is a kind of rare disease. Due to the complexity of CL, clinicians should consider both disease components in order to increase the likelihood of effective treatment. This is important.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Vincristine
Dacarbazine
ABVD Regimen
Case Report
Bleomycin
Gastroenterology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Chidamide
hemic and lymphatic diseases
medicine
business.industry
General Medicine
medicine.disease
Lymphoma
Regimen
030104 developmental biology
chemistry
030220 oncology & carcinogenesis
Medicine
business
Progressive disease
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 23915463
- Volume :
- 15
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Open Medicine
- Accession number :
- edsair.doi.dedup.....68484be2f5d52246942ff71411f311b0