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Endothelināconverting enzymes
- Source :
- The FASEB Journal. 6:2653-2659
- Publication Year :
- 1992
- Publisher :
- Wiley, 1992.
-
Abstract
- The putative endothelin-converting enzyme (ECE) has been the focus of intense research, both within academia and the pharmaceutical industry. Interest in ECE stems mainly from the hypothesis that development of inhibitors of ECE will provide an effective means of preventing production of endothelin in circumstances where it may play a pathogenic role. Both an aspartic and a metalloprotease have been identified that have characteristics of this putative enzyme. Evidence suggests that the metalloprotease, which is inhibited by phosphoramidon, may be the physiologically relevant converting enzyme. However, it remains to be demonstrated conclusively that any inhibitor of an ECE activity directly alters endogenous endothelin production and/or the pathogenesis of a disease condition in which endothelin is thought to play a primary role.
- Subjects :
- Endothelin converting enzyme 1
Molecular Sequence Data
Endogeny
Endothelin-Converting Enzymes
Biochemistry
Pathogenesis
chemistry.chemical_compound
Genetics
Aspartic Acid Endopeptidases
Humans
Amino Acid Sequence
education
Molecular Biology
chemistry.chemical_classification
Metalloproteinase
education.field_of_study
biology
Endothelins
Phosphoramidon
Metalloendopeptidases
Enzyme
chemistry
Enzyme inhibitor
biology.protein
Endothelin receptor
Biotechnology
Subjects
Details
- ISSN :
- 15306860 and 08926638
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- The FASEB Journal
- Accession number :
- edsair.doi.dedup.....68587571cbb222627b8800e5c7aa94ae