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Peptide YY and Glucagon-like Peptide-1 in Morbidly Obese Patients Before and After Surgically Induced Weight Loss

Peptide YY and Glucagon-like Peptide-1 in Morbidly Obese Patients Before and After Surgically Induced Weight Loss

Authors :
Hans Peter Kopp
Thomas Reinehr
Gerit-Holger Schernthaner
Christian L. Roth
Guntram Schernthaner
Stefan Kriwanek
Source :
Obesity Surgery. 17:1571-1577
Publication Year :
2007
Publisher :
Springer Science and Business Media LLC, 2007.

Abstract

Peptide YY (PYY) and glucagon-like peptide-1 (GLP-1) are cosecreted in the same enteroendocrine L-cells of the gut and reported to inhibit food intake additively. However, findings in human studies regarding these peptides are controversial. The aim of this study was to analyze the relationships between fasting PYY, GLP-1, and weight status in morbidly obese patients before and after surgically induced weight loss. Fasting GLP-1, PYY, glucose, and insulin concentrations; blood pressure; and body-mass index (BMI) were determined in 30 morbidly obese adults (mean BMI 45.8, mean age 40 years) before bariatric surgery [Roux-en-Y gastric bypass (RYGB): n = 19; gastric banding (GB): n = 11] and after weight loss (mean 50% excess weight loss) in the course of mean 2 years. GLP-1 concentrations decreased (mean −20 pg/ml; mean −38%; p = 0.001) and PYY concentrations increased (mean +19 pg/ml; mean +19%, p = 0.036) after bariatric surgery. The weight loss and changes of GLP-1 were significantly (p

Details

ISSN :
17080428 and 09608923
Volume :
17
Database :
OpenAIRE
Journal :
Obesity Surgery
Accession number :
edsair.doi.dedup.....687e42b28d4d1d57bb22e82199447be5
Full Text :
https://doi.org/10.1007/s11695-007-9323-8