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Peptide YY and Glucagon-like Peptide-1 in Morbidly Obese Patients Before and After Surgically Induced Weight Loss
Peptide YY and Glucagon-like Peptide-1 in Morbidly Obese Patients Before and After Surgically Induced Weight Loss
- Source :
- Obesity Surgery. 17:1571-1577
- Publication Year :
- 2007
- Publisher :
- Springer Science and Business Media LLC, 2007.
-
Abstract
- Peptide YY (PYY) and glucagon-like peptide-1 (GLP-1) are cosecreted in the same enteroendocrine L-cells of the gut and reported to inhibit food intake additively. However, findings in human studies regarding these peptides are controversial. The aim of this study was to analyze the relationships between fasting PYY, GLP-1, and weight status in morbidly obese patients before and after surgically induced weight loss. Fasting GLP-1, PYY, glucose, and insulin concentrations; blood pressure; and body-mass index (BMI) were determined in 30 morbidly obese adults (mean BMI 45.8, mean age 40 years) before bariatric surgery [Roux-en-Y gastric bypass (RYGB): n = 19; gastric banding (GB): n = 11] and after weight loss (mean 50% excess weight loss) in the course of mean 2 years. GLP-1 concentrations decreased (mean −20 pg/ml; mean −38%; p = 0.001) and PYY concentrations increased (mean +19 pg/ml; mean +19%, p = 0.036) after bariatric surgery. The weight loss and changes of GLP-1 were significantly (p
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
Gastroplasty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Gastric Bypass
Radioimmunoassay
Blood Pressure
Enzyme-Linked Immunosorbent Assay
Statistics, Nonparametric
Body Mass Index
Glucagon-Like Peptide 1
Weight loss
Internal medicine
Weight Loss
Humans
Insulin
Medicine
Peptide YY
Postoperative Period
Nutrition and Dietetics
business.industry
digestive, oral, and skin physiology
Middle Aged
medicine.disease
Glucagon-like peptide-1
Obesity
Obesity, Morbid
Blood pressure
Endocrinology
Female
Surgery
medicine.symptom
business
Body mass index
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 17080428 and 09608923
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Obesity Surgery
- Accession number :
- edsair.doi.dedup.....687e42b28d4d1d57bb22e82199447be5
- Full Text :
- https://doi.org/10.1007/s11695-007-9323-8