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Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors
- Source :
- Antimicrobial agents and chemotherapy, vol 66, iss 10, Antimicrob Agents Chemother
- Publication Year :
- 2022
- Publisher :
- eScholarship, University of California, 2022.
-
Abstract
- The proteasome is a promising target for antimalarial chemotherapy. We assessed ex vivo susceptibilities of fresh Plasmodium falciparum isolates from eastern Uganda to seven proteasome inhibitors: two asparagine ethylenediamines, two macrocyclic peptides, and three peptide boronates; five had median IC(50) values
- Subjects :
- Falciparum
Proteasome Endopeptidase Complex
Plasmodium falciparum
Drug Resistance
Microbiology
Antimalarials
Rare Diseases
Mechanisms of Resistance
Genetics
Humans
Pharmacology (medical)
Uganda
Malaria, Falciparum
antimalarial agents
Pharmacology
Pharmacology and Pharmaceutical Sciences
Ethylenediamines
Malaria
Vector-Borne Diseases
proteasome
Infectious Diseases
Good Health and Well Being
5.1 Pharmaceuticals
Medical Microbiology
Asparagine
Development of treatments and therapeutic interventions
Peptides
Proteasome Inhibitors
Biotechnology
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Antimicrobial agents and chemotherapy, vol 66, iss 10, Antimicrob Agents Chemother
- Accession number :
- edsair.doi.dedup.....68bc34406b4545749259203028861266