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The History and Future of Probenecid
- Source :
- Cardiovascular Toxicology. 12:1-9
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- Probenecid was initially developed with the goal of reducing the renal excretion of antibiotics, specifically penicillin. It is still used for its uricosuric properties in the treatment in gout, but its clinical relevance has sharply fallen and is rarely used today for either. Interestingly, throughout the last 60 years, there have been a host of apparently unrelated studies using probenecid in the clinical and basic research arena, including its potential use in the diagnosis and treatment of depression and its use to prevent fura-2 leakage in calcium transient studies. Recently, it has been shown that it is also an agonist of the Transient Receptor Potential Vanilloid 2 channel. Due to its unique action and new findings implicating TRPV channels in physiology and in disease, probenecid may have a new future as a research tool, and perhaps as a clinical agent in the neurology and cardiology fields. We review the history of probenecid in this paper and its potential future uses.
- Subjects :
- Agonist
medicine.medical_specialty
Neurology
Uricosuric
Gout
medicine.drug_class
TRPV Cation Channels
Pharmacology
Toxicology
TRPV
Transient receptor potential channel
Animals
Humans
Medicine
Molecular Biology
Depression
Probenecid
business.industry
Uricosuric Agents
medicine.disease
Anti-Bacterial Agents
Penicillin
Fura-2
Cardiology and Cardiovascular Medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 15590259 and 15307905
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Toxicology
- Accession number :
- edsair.doi.dedup.....68d4bc4551f0fb45721ca471f47fd9b0