Ação do verapamil, bloqueador de canais de calcio, sobre o desenvolvimento do germe dentario de ratos e sua correlação com os teores sericos de calcio

Orientador: Jose Ranali, Wilma P. Bastos Ramos Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba Resumo: Tendo em vista que os bloqueadores dos canais de cálcio, são utilizados na terapêutica, geralmente, por longos períodos de tempo, muitas vezes em gestantes, propôs-se estudar neste trabalho, os efeitos do verapamil sobre o germe dentário de filhotes de ratas tratadas com a droga, antes e durante a prenhez. Avaliou-se os efeitos da droga sobre implantações uterinas, reabsorções fetais, desenvolvimento ósseo e níveis plasmáticos de cálcio, fosfatos e proteínas totais em mães e filhotes. Utilizou-se 73 ratos Wistar...Observação: O resumo, na íntegra, poderá ser visualizado no texto completo da tese digital Abstract: Calcium channel blockers are widely used in therapeutics, usually in long term treatments, often in pregnant women. It was intended, this occasion, to study the effects of verapamil on dental germ of new-born from mothers treated with this drug, before and during pregnancy. It was studied the effects of the drug on uterine implantation, fetal reabsorption, bone development and serum levels of calcium, phosphate and total proteins in mothers and new-born. It was used 73 Wistar rats (Ratus norvergicus, varoAlbinus), quality controlled. The female were randomly divided in 3 groups, as fa11ows: the first received verapamil in doses of 24 mg/ratlEtay,named group (01) the second received the drug in doses of 2.4 mg/ratlday, named group (02); the third was a control group. The rats were kept in individual cases and received the drug in the drinking water during 10 weeks: 7 weeks before mating and three weeks during pregnancy. The cesarean surgery was performed at the 21st day. This occasion, heparinized blood samples were taken (to biochemical determinations) as well as isolated the femoral bone (to bone development determination). The new-born heads were isolated to histology of dental germs and taken blood samples to biochemical determinations...Note: The complete abstract is available with the full electronic digital thesis or dissertations Mestrado Farmacologia Mestre em Ciências