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The relevance of cell size on ultrasound-induced hemolysis in mouse and human blood in vitro
- Source :
- Ultrasound in medicinebiology. 29(10)
- Publication Year :
- 2003
-
Abstract
- This paper describes a further test of the hypothesis that cell size is an important physical parameter in ultrasound (US)-induced hemolysis, that is, the larger the cell the greater the potential for sonolysis by a cavitational mechanism. Mouse (M) and human (Hu) erythrocytes in vitro were used; their mean corpuscular volumes were 49.0 and 89.5 fL, respectively. At a US exposure in vitro in the presence of Albunex that yielded an average of 36.8% hemolysis for M blood, the Hu blood yielded an average of 54.0% hemolysis. The data supported the hypothesis. This paper also briefly discusses the difficulty of extrapolating sonolytic in vitro results to those derived in vivo.
- Subjects :
- Erythrocyte Indices
Pathology
medicine.medical_specialty
Erythrocytes
Acoustics and Ultrasonics
Cell
Biophysics
Contrast Media
In Vitro Techniques
Hemolysis
Cell size
Andrology
Mice
Species Specificity
In vivo
medicine
Animals
Humans
Radiology, Nuclear Medicine and imaging
Cell Size
Ultrasonography
Radiological and Ultrasound Technology
Human blood
business.industry
Chemistry
Erythrocyte indices
Ultrasound
medicine.disease
In vitro
Mice, Inbred C57BL
medicine.anatomical_structure
business
Subjects
Details
- ISSN :
- 03015629
- Volume :
- 29
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Ultrasound in medicinebiology
- Accession number :
- edsair.doi.dedup.....68f75e270493a08bb593ccb239b885bf