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The relevance of cell size on ultrasound-induced hemolysis in mouse and human blood in vitro

Authors :
Linda F Battaglia
Morton W. Miller
Source :
Ultrasound in medicinebiology. 29(10)
Publication Year :
2003

Abstract

This paper describes a further test of the hypothesis that cell size is an important physical parameter in ultrasound (US)-induced hemolysis, that is, the larger the cell the greater the potential for sonolysis by a cavitational mechanism. Mouse (M) and human (Hu) erythrocytes in vitro were used; their mean corpuscular volumes were 49.0 and 89.5 fL, respectively. At a US exposure in vitro in the presence of Albunex that yielded an average of 36.8% hemolysis for M blood, the Hu blood yielded an average of 54.0% hemolysis. The data supported the hypothesis. This paper also briefly discusses the difficulty of extrapolating sonolytic in vitro results to those derived in vivo.

Details

ISSN :
03015629
Volume :
29
Issue :
10
Database :
OpenAIRE
Journal :
Ultrasound in medicinebiology
Accession number :
edsair.doi.dedup.....68f75e270493a08bb593ccb239b885bf