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Favipiravir Inhibits Mayaro Virus Infection in Mice
- Source :
- Viruses, Viruses, 2021, 13 (11), pp.2213. ⟨10.3390/v13112213⟩, Viruses, Vol 13, Iss 2213, p 2213 (2021), Volume 13, Issue 11
- Publication Year :
- 2021
-
Abstract
- International audience; Mayaro virus (MAYV) is an emergent alphavirus that causes MAYV fever. It is often associated with debilitating symptoms, particularly arthralgia and myalgia. MAYV infection is becoming a considerable health issue that, unfortunately, lacks a specific antiviral treatment. Favipiravir, a broad-spectrum antiviral drug, has recently been shown to exert anti-MAYV activity in vitro. In the present study, the potential of Favipiravir to inhibit MAYV replication in an in vivo model was evaluated. Immunocompetent mice were orally administrated 300 mg/kg/dose of Favipiravir at pre-, concurrent-, or post-MAYV infection. The results showed a significant reduction in infectious viral particles and viral RNA transcripts in the tissues and blood of the pre- and concurrently treated infected mice. A significant reduction in the presence of both viral RNA transcript and infectious viral particles in the tissue and blood of pre- and concurrently treated infected mice was observed. By contrast, Favipiravir treatment post-MAYV infection did not result in a reduction in viral replication. Interestingly, Favipiravir strongly decreased the blood levels of the liver disease markers aspartate- and alanine aminotransferase in the pre- and concurrently treated MAYV-infected mice. Taken together, these results suggest that Favipiravir is a potent antiviral drug when administered in a timely manner.
- Subjects :
- mayaro
Virus Replication
Liver disease
Mice
Chlorocebus aethiops
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology
[SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases
0303 health sciences
[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases
biology
Alanine Transaminase
QR1-502
3. Good health
Infectious Diseases
Liver
Pyrazines
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Female
antiviral drug
medicine.drug_class
Alphavirus
Favipiravir
favipiravir
Microbiology
Antiviral Agents
Virus
Article
Cell Line
03 medical and health sciences
In vivo
Virology
medicine
Animals
Aspartate Aminotransferases
Vero Cells
030304 developmental biology
030306 microbiology
business.industry
Alphavirus Infections
biology.organism_classification
medicine.disease
Amides
In vitro
Mice, Inbred C57BL
Disease Models, Animal
arbovirus
Viral replication
Antiviral drug
business
Subjects
Details
- ISSN :
- 19994915
- Volume :
- 13
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Viruses
- Accession number :
- edsair.doi.dedup.....690b66a444e2c411a210815d28fb2a35