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Friend or Foe: S100 Proteins in Cancer

Authors :
Johannes Lemke
Chantal Allgöwer
Mathias Wittau
Doris Henne-Bruns
Silvia von Karstedt
Anna-Laura Kretz
Source :
Cancers, Cancers, Vol 12, Iss 2037, p 2037 (2020)
Publication Year :
2020
Publisher :
MDPI AG, 2020.

Abstract

S100 proteins are widely expressed small molecular EF-hand calcium-binding proteins of vertebrates, which are involved in numerous cellular processes, such as Ca2+ homeostasis, proliferation, apoptosis, differentiation, and inflammation. Although the complex network of S100 signalling is by far not fully deciphered, several S100 family members could be linked to a variety of diseases, such as inflammatory disorders, neurological diseases, and also cancer. The research of the past decades revealed that S100 proteins play a crucial role in the development and progression of many cancer types, such as breast cancer, lung cancer, and melanoma. Hence, S100 family members have also been shown to be promising diagnostic markers and possible novel targets for therapy. However, the current knowledge of S100 proteins is limited and more attention to this unique group of proteins is needed. Therefore, this review article summarises S100 proteins and their relation in different cancer types, while also providing an overview of novel therapeutic strategies for targeting S100 proteins for cancer treatment.

Details

ISSN :
20726694
Volume :
12
Database :
OpenAIRE
Journal :
Cancers
Accession number :
edsair.doi.dedup.....6919724919a650e97c8cfd434df5836e
Full Text :
https://doi.org/10.3390/cancers12082037