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Medicinal Value and Potential Therapeutic Mechanisms of Gynostemma pentaphyllum (Thunb.) Makino and Its Derivatives: An Overview
- Source :
- Current topics in medicinal chemistry. 19(31)
- Publication Year :
- 2019
-
Abstract
- Gynostemma pentaphyllum (Thunb.) Makino (GpM) and its derivatives, especially gypenosides (Gyps), are widely used as safe and convenient natural herbal drugs for the treatment of many diseases for a long time, and Gyps have different oral bioavailability (OB) values and low ability to cross the blood-brain barrier (BBB). The effects of GpM and isolates on fibrosis, inflammation, oxidation, proliferation and migration are proved. GpM shows bidirectional regulation effect on proliferation, oxidation and apoptosis in tumor and non-tumor cells. GpM and its extractions can resist proliferation, activate oxidation and apoptosis in tumor cells and have opposite effects on non-tumor cells. We succinctly present some current views of medicinal value and potential therapeutic mechanisms of GpM and its derivatives.
- Subjects :
- 0301 basic medicine
Molecular Conformation
Inflammation
Tumor cells
Pharmacology
03 medical and health sciences
0302 clinical medicine
Neoplasms
Drug Discovery
medicine
Humans
Gynostemma pentaphyllum
Cell Proliferation
biology
Chemistry
General Medicine
biology.organism_classification
Gynostemma
Pharmacological action
Bioavailability
030104 developmental biology
Apoptosis
Blood-Brain Barrier
030220 oncology & carcinogenesis
medicine.symptom
Drugs, Chinese Herbal
Subjects
Details
- ISSN :
- 18734294
- Volume :
- 19
- Issue :
- 31
- Database :
- OpenAIRE
- Journal :
- Current topics in medicinal chemistry
- Accession number :
- edsair.doi.dedup.....69208d8e153bd6a7107fca65a7814afc