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Cortical control of saccade in normal and schizophrenic subjects: a PET study using a task-evoked rCBF paradigm
- Source :
- Schizophrenia Research. 12:259-264
- Publication Year :
- 1994
- Publisher :
- Elsevier BV, 1994.
-
Abstract
- In this study, positron emission tomography (PET) was used to evaluate cortical control of saccades. Regional cerebral blood flow (rCBF) patterns demonstrated by 15 O water PET during saccadic task performance were tested in 13 normal volunteers and 20 ICD-9 schizo phrenics (10 unmedicated and 10 medicated). The following 3 saccadic tasks, which were controlled for sensory input and oculomotor output, were applied: (1) reflexive saccade = visually guided saccade, (2) volitional saccade = visually guided saccade with distracting stimuli, and (3) memory guided saccade. Schizophrenics lacked the frontal eye field (FEF) activation during every saccadic task. The left dorsolateral prefrontal cortex (DLPFC) was activated during volitional saccade only in normal controls. The rCBF of posterior parietal cortex increased in pararell with that in the DLPFC. These findings suggest functional hypofrontality in schizophrenia and the left DLPFC-PPC's crucial role in saccade against distracting stimuli and its dysfunction in the disease.
- Subjects :
- Adult
Male
Psychosis
Adolescent
genetic structures
Posterior parietal cortex
Hypofrontality
behavioral disciplines and activities
Task Performance and Analysis
Saccades
medicine
Humans
Prefrontal cortex
Biological Psychiatry
Cerebral Cortex
Electroencephalography
medicine.disease
Saccadic masking
Electrooculography
Psychiatry and Mental health
nervous system
Cerebral blood flow
Regional Blood Flow
Schizophrenia
Cerebrovascular Circulation
Saccade
Female
Psychology
Neuroscience
psychological phenomena and processes
Tomography, Emission-Computed
Subjects
Details
- ISSN :
- 09209964
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Schizophrenia Research
- Accession number :
- edsair.doi.dedup.....694bd5a30edbf97c132f438212b8d3ec
- Full Text :
- https://doi.org/10.1016/0920-9964(94)90036-1