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Efficacy of Combination Drug Pulse Therapy in Maintaining Lipid Levels in Patients Intolerant of Daily Statin Use
- Source :
- J Clin Hypertens (Greenwich)
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- The objective of this study was to evaluate the efficacy of combination drug pulse therapy in maintaining lipid levels in patients intolerant of a daily dose of statins. Twenty‐three patients, previously receiving aggressive statin therapy, were treated twice weekly with rosuvastatin or atorvastatin in different dosages along with ezetimibe as well as daily doses of bile acid sequestrant for a mean period of 4.5 months. The recommended National Cholesterol Education Program Adult Treatment Panel III goals had already been achieved in 78% of patients (n=18) before starting combination pulse therapy. This combination therapy significantly increased high‐density lipoprotein cholesterol values by 5.82% (t=2.138, P=.044), while the increases in total cholesterol, low‐density lipoprotein cholesterol, triglyceride, and apolipoprotein B levels compared with baseline were not statistically significant. Overall, 3 of 23 patients (13%) discontinued the combination therapy because of muscle‐related symptoms over a mean course of 4.5 months of treatment.
- Subjects :
- Male
Endocrinology, Diabetes and Metabolism
Atorvastatin
Colesevelam Hydrochloride
Gastroenterology
chemistry.chemical_compound
Rosuvastatin Calcium
Sulfonamides
Anticholesteremic Agents
Middle Aged
Lipids
Drug Therapy, Combination
Female
lipids (amino acids, peptides, and proteins)
Drug Monitoring
Cardiology and Cardiovascular Medicine
Combination drug
medicine.drug
medicine.medical_specialty
Combination therapy
medicine.drug_class
Hyperlipidemias
Journal of the CardioMetabolic Syndrome
Allylamine
Ezetimibe
Bile acid sequestrant
Internal medicine
Internal Medicine
medicine
Humans
Pyrroles
Rosuvastatin
National Cholesterol Education Program
Apolipoproteins B
Retrospective Studies
Analysis of Variance
Triglyceride
business.industry
Cholesterol, LDL
Fluorobenzenes
Pyrimidines
Endocrinology
chemistry
Heptanoic Acids
Pulse Therapy, Drug
Azetidines
Hydroxymethylglutaryl-CoA Reductase Inhibitors
business
Subjects
Details
- ISSN :
- 17517176 and 15246175
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- The Journal of Clinical Hypertension
- Accession number :
- edsair.doi.dedup.....694e71c15a449354c6e140dbe4ed4fd4