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Advancing the delivery of anticancer drugs: Conjugated polymer/triterpenoid composite
- Source :
- Acta biomaterialia. 19
- Publication Year :
- 2014
-
Abstract
- Exemplifying the synergy of anticancer properties of triterpenoids and ion retention qualities of conjugated polymers, we propose a conducting matrix to be a reservoir of anticancer compounds. In this study, poly(3,4-ethylenedioxythiophene), PEDOT, based matrix for electrically triggered and local delivery of the ionic form of anticancer drug, oleanolic acid (HOL), has been investigated. An initial, one-step fabrication procedure has been proposed, providing layers exhibiting good drug release properties and biological activity. Investigation of obtained systems and implementation of modifications revealed another route of fabrication. This procedure was found to yield layers possessing a significantly greater storage capacity of OL(-), as evidenced by the 52% increase in the drug concentrations attainable through electro-assisted release. Examination of the biological activity of immobilised and released OL(-) molecules proved that electrochemical treatment has negligible impact on the anticancer properties of OL(-), particularly when employing the three-step procedure, in which the range of applied potentials is limited. PEDOT/OL(-) composite has been demonstrated to be a robust and cost-effective material for controlled drug delivery.
- Subjects :
- Materials science
Polymers
Biomedical Engineering
Antineoplastic Agents
Nanoconjugates
Conjugated system
Biochemistry
Nanocapsules
Nanocomposites
Biomaterials
Diffusion
chemistry.chemical_compound
PEDOT:PSS
Materials Testing
Organic chemistry
Oleanolic Acid
Particle Size
Molecular Biology
chemistry.chemical_classification
Conductive polymer
Nanocomposite
General Medicine
Polymer
Bridged Bicyclo Compounds, Heterocyclic
Triterpenes
chemistry
Delayed-Action Preparations
Drug delivery
Poly(3,4-ethylenedioxythiophene)
Biotechnology
Subjects
Details
- ISSN :
- 18787568
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Acta biomaterialia
- Accession number :
- edsair.doi.dedup.....69621a0c3140c38f618409d073c6efd3