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Toward a Total Synthesis of Peloruside A: Enantioselective Preparation of the C8−C19 Region
- Source :
- Organic Letters. 5:4959-4961
- Publication Year :
- 2003
- Publisher :
- American Chemical Society (ACS), 2003.
-
Abstract
- An efficient synthetic sequence toward the C8-C19 region of peloruside A has been developed. The route is highlighted by a selective electrophilic cyclization reaction, a single-step epoxide ring-opening/methylation sequence, and a stereoselective Mukaiyama aldol reaction. [reaction: see text]
- Subjects :
- Magnetic Resonance Spectroscopy
Alkylation
Chemical Phenomena
Chemistry, Physical
Chemistry
Stereochemistry
Organic Chemistry
Enantioselective synthesis
Epoxide
Total synthesis
Stereoisomerism
Methylation
Bridged Bicyclo Compounds, Heterocyclic
Biochemistry
Porifera
Lactones
chemistry.chemical_compound
Aldol reaction
Electrophile
Animals
Peloruside A
Indicators and Reagents
Stereoselectivity
Physical and Theoretical Chemistry
Subjects
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Organic Letters
- Accession number :
- edsair.doi.dedup.....696976b03056a9dac10794573c9dcb37